ENSMUSG00000006469


Mus musculus

Features
Gene ID: ENSMUSG00000006469
  
Biological name :Slc34a3
  
Synonyms : Q80SU6 / Slc34a3 / solute carrier family 34 (sodium phosphate), member 3
  
Possible biological names infered from orthology : Q8N130 / solute carrier family 34 member 3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 25228898
Gene end: 25234364
  
Corresponding Affymetrix probe sets: 10480633 (MoGene1.0st)   1439519_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006638
NCBI entrez gene - 142681     See in Manteia.
MGI - MGI:2159410
RefSeq - XM_017315541
RefSeq - NM_080854
RefSeq - XM_011239018
RefSeq - XM_017315536
RefSeq - XM_006497677
RefSeq - XM_006497678
RefSeq - XM_006497679
RefSeq - XM_006497681
RefSeq - XM_006497682
RefSeq - XM_006497683
RefSeq - XM_011239017
RefSeq Peptide - NP_543130
swissprot - Q80SU6
Ensembl - ENSMUSG00000006469
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8N130ENSG00000198569Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DBP0 / Slc34a2 / solute carrier family 34 (sodium phosphate), member 2 / O95436* / solute carrier family 34 member 2*ENSMUSG0000002918851
Slc34a1 / solute carrier family 34 (sodium phosphate), member 1 / Q06495* / solute carrier family 34 member 1*ENSMUSG0000002149049


Protein motifs (from Interpro)
Interpro ID Name
 IPR003841  Sodium-dependent phosphate transport protein
 IPR029850  Sodium-dependent phosphate transport protein 2C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport ISO
 biological_processGO:0006817 phosphate ion transport IEA
 biological_processGO:0030643 cellular phosphate ion homeostasis IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0044341 sodium-dependent phosphate transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0031982 vesicle IBA
 molecular_functionGO:0005436 sodium:phosphate symporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015321 sodium-dependent phosphate transmembrane transporter activity ISO


Pathways (from Reactome)
Pathway description
Type II Na+/Pi cotransporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0002905 decreased circulating parathyroid hormone level "less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0003116 rickets "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0010110 abnormal renal phosphate reabsorption "any anomaly in the process by which phosphate (salt or ester of phosphoric acid) is transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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