ENSMUSG00000021490


Mus musculus

Features
Gene ID: ENSMUSG00000021490
  
Biological name :Slc34a1
  
Synonyms : Slc34a1 / solute carrier family 34 (sodium phosphate), member 1
  
Possible biological names infered from orthology : Q06495 / solute carrier family 34 member 1
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 55398187
Gene end: 55415592
  
Corresponding Affymetrix probe sets: 10405448 (MoGene1.0st)   10405462 (MoGene1.0st)   1423279_at (Mouse Genome 430 2.0 Array)   1427627_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153038
Ensembl peptide - ENSMUSP00000059138
Ensembl peptide - ENSMUSP00000152974
NCBI entrez gene - 20505     See in Manteia.
MGI - MGI:1345284
RefSeq - NM_011392
RefSeq - XM_006517177
RefSeq - XM_006517178
RefSeq Peptide - NP_035522
swissprot - A0A286YCG7
swissprot - Q9D2V6
Ensembl - ENSMUSG00000021490
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc34a1aENSDARG00000028824Danio rerio
 slc34a1bENSDARG00000054658Danio rerio
 SLC34A1ENSGALG00000003075Gallus gallus
 Q06495ENSG00000131183Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DBP0 / Slc34a2 / solute carrier family 34 (sodium phosphate), member 2 / O95436* / solute carrier family 34 member 2*ENSMUSG0000002918855
Q80SU6 / Slc34a3 / solute carrier family 34 (sodium phosphate), member 3 / Q8N130* / solute carrier family 34 member 3*ENSMUSG0000000646946


Protein motifs (from Interpro)
Interpro ID Name
 IPR003841  Sodium-dependent phosphate transport protein
 IPR029848  Sodium-dependent phosphate transport protein 2A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006817 phosphate ion transport IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009100 glycoprotein metabolic process IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0035864 response to potassium ion IEA
 biological_processGO:0042431 indole metabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0044341 sodium-dependent phosphate transport IEA
 biological_processGO:0045838 positive regulation of membrane potential IEA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0046689 response to mercury ion IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0055062 phosphate ion homeostasis IEA
 biological_processGO:0060416 response to growth hormone IEA
 biological_processGO:0071107 response to parathyroid hormone IEA
 biological_processGO:0071248 cellular response to metal ion IEA
 biological_processGO:0071374 cellular response to parathyroid hormone stimulus IEA
 biological_processGO:0072350 tricarboxylic acid metabolic process IEA
 biological_processGO:0072734 cellular response to staurosporine IEA
 biological_processGO:0097066 response to thyroid hormone IEA
 biological_processGO:0097187 dentinogenesis IEA
 biological_processGO:1901128 gentamycin metabolic process IEA
 biological_processGO:1901652 response to peptide IEA
 biological_processGO:1901684 arsenate ion transmembrane transport IEA
 biological_processGO:2000120 positive regulation of sodium-dependent phosphate transport IEA
 biological_processGO:2000187 positive regulation of phosphate transmembrane transport IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 molecular_functionGO:0015321 sodium-dependent phosphate transmembrane transporter activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Type II Na+/Pi cotransporters
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0002905 decreased circulating parathyroid hormone level "less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003116 rickets "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0010110 abnormal renal phosphate reabsorption "any anomaly in the process by which phosphate (salt or ester of phosphoric acid) is transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten,Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic Background: B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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