ENSMUSG00000029188


Mus musculus

Features
Gene ID: ENSMUSG00000029188
  
Biological name :Slc34a2
  
Synonyms : Q9DBP0 / Slc34a2 / solute carrier family 34 (sodium phosphate), member 2
  
Possible biological names infered from orthology : O95436 / solute carrier family 34 member 2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C1
Gene start: 53038081
Gene end: 53071664
  
Corresponding Affymetrix probe sets: 10521892 (MoGene1.0st)   1416854_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130692
Ensembl peptide - ENSMUSP00000092380
NCBI entrez gene - 20531     See in Manteia.
MGI - MGI:1342284
RefSeq - NM_011402
RefSeq - XM_006503807
RefSeq Peptide - NP_035532
swissprot - E9QAX5
swissprot - Q9DBP0
Ensembl - ENSMUSG00000029188
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc34a2aENSDARG00000012903Danio rerio
 slc34a2bENSDARG00000036864Danio rerio
 SLC34A2ENSGALG00000014372Gallus gallus
 O95436ENSG00000157765Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc34a1 / solute carrier family 34 (sodium phosphate), member 1 / Q06495* / solute carrier family 34 member 1*ENSMUSG0000002149051
Q80SU6 / Slc34a3 / solute carrier family 34 (sodium phosphate), member 3 / Q8N130* / solute carrier family 34 member 3*ENSMUSG0000000646944


Protein motifs (from Interpro)
Interpro ID Name
 IPR003841  Sodium-dependent phosphate transport protein
 IPR029852  Sodium-dependent phosphate transport protein 2B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006817 phosphate ion transport IEA
 biological_processGO:0030643 cellular phosphate ion homeostasis IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0044341 sodium-dependent phosphate transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031982 vesicle IBA
 molecular_functionGO:0005436 sodium:phosphate symporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015321 sodium-dependent phosphate transmembrane transporter activity ISO
 molecular_functionGO:0031402 sodium ion binding IEA
 molecular_functionGO:0042301 phosphate ion binding IEA


Pathways (from Reactome)
Pathway description
Type II Na+/Pi cotransporters
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dscamtm1Pfu/Dscamtm1Pfu,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129 * C57BL/6

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dscamtm1Pfu/Dscamtm1Pfu,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129 * C57BL/6

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dscamtm1Pfu/Dscamtm1Pfu,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129 * C57BL/6

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
Show

Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0002902 hypophosphaturia "a reduction of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H

Allelic Composition: Slc34a2tm1Sega/Slc34a2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JJcl

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
Show

Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
Show

Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dscamtm1Pfu/Dscamtm1Pfu,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129 * C57BL/6

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Dscamtm1Pfu/Dscamtm1Pfu,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129 * C57BL/6

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc34a2tm1Sega/Slc34a2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JJcl

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc34a2tm1Sega/Slc34a2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JJcl

 MP:0010923 pulmonary alveolar calcification "pathologic deposition of calcium salts in the pulmonary alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Dscamtm1Pfu/Dscamtm1Pfu,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129 * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Slc34a2tm1Sega/Slc34a2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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