Manteia - Molecule gene

ENSMUSG00000006471

Mus musculus

Features

Gene ID:	ENSMUSG00000006471

Biological name :	Ndor1

Synonyms :	A2AI05 / NADPH-dependent diflavin oxidoreductase 1 / Ndor1

Possible biological names infered from orthology :	Q9UHB4

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	A3
Gene start:	25244821
Gene end:	25256022

Corresponding Affymetrix probe sets:	10480652 (MoGene1.0st) 1428292_at (Mouse Genome 430 2.0 Array) 1435388_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000125018 Ensembl peptide - ENSMUSP00000109989 Ensembl peptide - ENSMUSP00000125259 Ensembl peptide - ENSMUSP00000123247 Ensembl peptide - ENSMUSP00000123958 Ensembl peptide - ENSMUSP00000097903 NCBI entrez gene - 78797 See in Manteia. MGI - MGI:1926047 RefSeq - XM_006498443 RefSeq - XM_006498444 RefSeq - XM_006498450 RefSeq - XM_006498447 RefSeq - XM_006498446 RefSeq - NM_001082476 RefSeq - NM_001252541 RefSeq - XM_006498451 RefSeq - XM_006498445 RefSeq Peptide - NP_001239470 RefSeq Peptide - NP_001075945 swissprot - E0CYR1 swissprot - A2AI05 swissprot - F6XCS1 swissprot - E0CX27 swissprot - E0CXI9 Ensembl - ENSMUSG00000006471

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ndor1	ENSDARG00000007429	Danio rerio
NDOR1	ENSGALG00000008920	Gallus gallus
NDOR1	ENSG00000188566	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
AL732309.2 / NDOR1* / Q9UHB4* / NADPH dependent diflavin oxidoreductase 1*	ENSMUSG00000115074	77
Mtrr / 5-methyltetrahydrofolate-homocysteine methyltransferase reductase / Q9UBK8*	ENSMUSG00000034617	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR001094	Flavodoxin-like
IPR001433	Oxidoreductase FAD/NAD(P)-binding
IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097	FAD-binding, type 1
IPR008254	Flavodoxin/nitric oxide synthase
IPR017927	Ferredoxin reductase-type FAD-binding domain
IPR017938	Riboflavin synthase-like beta-barrel
IPR028879	NADPH-dependent diflavin oxidoreductase 1
IPR029039	Flavoprotein-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0008219	cell death	ISO
biological_process	GO:0036245	cellular response to menadione	ISO
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISS
cellular_component	GO:0045111	intermediate filament cytoskeleton	ISO
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
molecular_function	GO:0003958	NADPH-hemoprotein reductase activity	IEA
molecular_function	GO:0010181	FMN binding	IEA
molecular_function	GO:0016491	oxidoreductase activity	ISO
molecular_function	GO:0050660	flavin adenine dinucleotide binding	ISO
molecular_function	GO:0050661	NADP binding	ISO

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000061	fragile skeleton	"easily damaged or broken bones" [J:14208]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0000066	osteoporosis	"reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000133	abnormal long bone metaphysis morphology	"malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4)Plj}/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * C57BL/6
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/? Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000255	vasculature congestion	"obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Kitl^tm2.1Sjm/Kitl^tm2.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL Allelic Composition: Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/? Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4)Plj}/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * C57BL/6
MP:0000423	delayed hair regrowth	"slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase " [J:61509]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000424	retarded hair growth	"slow growth of the hair, appears at normal time" [J:5476]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4)Plj}/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * C57BL/6
MP:0000427	abnormal hair cycle	"aberrant growth or asynchronous timing of the hair growth " [J:65302]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000488	abnormal intestinal epithelium morphology	"anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0000558	abnormal tibia morphology	"atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0000559	abnormal femur morphology	"structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000600	liver hypoplasia	"reduced size of liver due to decreased cell number " [J:57631]	Show Allelic Composition: Kitl^tm2.1Sjm/Kitl^tm2.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4)Plj}/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * C57BL/6
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4)Plj}/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * C57BL/6
MP:0000759	abnormal skeletal muscle morphology	"anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0001053	abnormal neuromuscular synapse	"malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]	Show Allelic Composition: Cacna1s^tm1.1Arte/Cacna1s^tm1.1Arte Genetic Background: involves: C57BL/6N
MP:0001153	small seminiferous tubules	"reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001200	thick skin	"greater depth of skin " [J:47225]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0001244	thin dermal layer	"reduced thickness of the dermis" [J:65030]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1.1Gqda,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Fto^tm1.1Rdc/Fto^tm1.1Rdc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Lin28a^tm1.1Gqda/Lin28a⁺,Lin28b^tm1.1Gqda/Lin28b^tm1.1Gqda Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N Allelic Composition: Lin28b^tm1Gqda/Lin28b^tm1.1Gqda,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4)Plj}/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * C57BL/6
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
MP:0001523	impaired righting response	"reduced ability or greater amount of time needed to recover from supine position" [J:25565]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4)Plj}/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * C57BL/6
MP:0001545	abnormal hematopoietic system physiology	"anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Kitl^tm2.1Sjm/Kitl^tm2.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0001711	abnormal placenta		Show Allelic Composition: Cnp^tm1(cre)Kan/Cnp⁺,Tfam^tm1Lrsn/Tfam^tm1Lrsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001723	disorganized vascular plexus		Show Allelic Composition: Cnp^tm1(cre)Kan/Cnp⁺,Tfam^tm1Lrsn/Tfam^tm1Lrsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001824	abnormal thymic involution	"premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0001859	kidney inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Ndufs4^tm1Rpa/Ndufs4^tm1Rpa,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0002060	abnormal skin morphology	"malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4)Plj}/Gt(ROSA)26Sor⁺,Tg(ACTA1-cre)79Jme/0 Genetic Background:* involves: C57BL/6 * SJL
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fto^tm1.1Rdc/Fto^tm1.1Rdc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0002086	abnormal extraembryonic tissue morphology	"structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cnp^tm1(cre)Kan/Cnp⁺,Tfam^tm1Lrsn/Tfam^tm1Lrsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002095	abnormal skin pigmentation	"variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0002335	decreased airway responsiveness	"less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0002397	abnormal bone marrow morphology	"structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0002416	abnormal proerythroblast morphology/development	"anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002795	dilated cardiomyopathy	"decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Kitl^tm2.1Sjm/Kitl^tm2.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0003111	abnormal nucleus morphology	"abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0003155	abnormal telomere length	"abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0003197	kidney calcification	"pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0003222	increased cardiomyocyte apoptosis	"increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0003229	abnormal vitelline vasculature	"malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]	Show Allelic Composition: Cnp^tm1(cre)Kan/Cnp⁺,Tfam^tm1Lrsn/Tfam^tm1Lrsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003380	abnormal intestine regeneration	"deviation from the normal ability of the intestine to regenerate healthy tissue following injury" [J:93428, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Wnt5a^tm1.1Tpy/Wnt5a^tm1.1Tpy,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0003408	increased width of hypertrophic chondrocyte zone	"increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0003701	elevated level of sister chromatid exchange	"increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:97667]	Show Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0003704	abnormal hair follicle development	"anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0003763	abnormal thymus physiology	"anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0003786	premature aging	"earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0003809	abnormal hair shaft morphology	"irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0003893	increased hepatocyte proliferation	"anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Fto^tm1.1Rdc/Fto^tm1.1Rdc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cnp^tm1(cre)Kan/Cnp⁺,Tfam^tm1Lrsn/Tfam^tm1Lrsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003985	renal fibrosis	"formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0004046	abnormal mitosis	"anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0004090	abnormal sarcomere morphology	"any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0004091	abnormal Z lines	"any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0004214	abnormal long bone diaphysis morphology	"any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0004231	abnormal calcium ion homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apc^Min/Apc⁺,Spata18^tm1.2Hifa/Spata18⁺ Genetic Background: involves: C57BL/6J
MP:0004509	abnormal pelvic girdle bone morphology	"any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0004543	abnormal sperm physiology	"anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apc^Min/Apc⁺,Spata18^tm1.2Hifa/Spata18⁺ Genetic Background: involves: C57BL/6J
MP:0004627	abnormal trochanter morphology	"any structural anomaly of the bony prominences near the upper extremity of the femur; there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third); these normally serve as attachment points for hip and thigh muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0004675	rib fractures	"a crack or break in the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/? Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0004841	abnormal small intestine crypts of Lieberkuhn morphology	"any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0004950	abnormal brain vasculature	"any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cnp^tm1(cre)Kan/Cnp⁺,Tfam^tm1Lrsn/Tfam^tm1Lrsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004970	kidney atrophy	"wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0004984	increased osteoclast cell number	"greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0004987	abnormal osteoblast cell number	"deviation from the average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0004991	decreased bone strength	"reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0004992	increased bone resorption	"greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/? Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005023	abnormal wound healing	"aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nlgn3^tm1Rhn/Y Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005166	decreased susceptiblity to injury	"less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0005290	decreased oxygen consumption	"less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Appl1^tm1.2Test/Appl1^tm1.2Test,Appl2^tm1.1Test/Appl2^tm1.1Test Genetic Background: involves: 129X1/SvJ
MP:0005597	decreased susceptibility to type I hypersensitivity reaction	"less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0006035	abnormal mitochondrial morphology	"anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0006036	abnormal mitochondrial physiology		Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0006207	embryonic lethality during organogenesis	"death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cnp^tm1(cre)Kan/Cnp⁺,Tfam^tm1Lrsn/Tfam^tm1Lrsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006397	disorganized long bone epiphyseal plate	"a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0006398	increased long bone epiphyseal plate size	"greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0008025	brain vacuoles	"the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0008042	abnormal NK T cell physiology	"any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Sh2d1a^tm1.1Knic/Sh2d1a^tm1.1Knic,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6 Allelic Composition: Sh2d1a^tm1.1Knic/Y,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
MP:0008142	decreased small intestinal villus size	"reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0008566	increased interferon-gamma secretion	"increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Hhat^{Tg(TFAP2A-cre)1Will}/Hhat⁺,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Sh2d1a^tm1.1Knic/Sh2d1a^tm1.1Knic,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6 Allelic Composition: Sh2d1a^tm1.1Knic/Y,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
MP:0008603	decreased circulating interleukin-4 level	"reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Sh2d1a^tm1.1Knic/Sh2d1a^tm1.1Knic,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6 Allelic Composition: Sh2d1a^tm1.1Knic/Y,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
MP:0008615	decreased circulating interleukin-17 level	"reduction in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]	Show Allelic Composition: Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2⁺ Genetic Background: C57BL/6-Tcf7l2^{tm1a(EUCOMM)Wtsi}
MP:0008753	abnormal osteocyte morphology	"any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi" [MESH:A.11.329.629.500]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0008803	abnormal placental labyrinth vasculature morphology	"any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cnp^tm1(cre)Kan/Cnp⁺,Tfam^tm1Lrsn/Tfam^tm1Lrsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0008941	reticulocytopenia	"decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
MP:0008964	decreased carbon dioxide production	"reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fto^tm1.1Rdc/Fto^tm1.1Rdc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0009278	abnormal bone marrow cell physiology	"any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myf5^tm3(cre)Sor/Myf5⁺,Stat5b^tm1Mam/Stat5b^tm1Mam Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac Allelic Composition: Kitl^tm2.1Sjm/Kitl^tm2.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL Allelic Composition: Gt(ROSA)26Sor^tm1Iaai/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^tm2Iaai/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0009283	decreased gonadal fat pad weight	"less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0009293	decreased inguinal fat pad weight		Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0009412	skeletal muscle fiber degeneration	"pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0009414	skeletal muscle fiber necrosis	"pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0009420	skeletal muscle endomysial fibrosis	"replacement of the layer of connective tissue that ensheaths a muscle fiber by fibrous tissue resulting in separation of individual fibers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0009445	osteomalacia	"gradual softening and bending of the bones due to failure of osteoid tissue to calcify as a result of vitamin D deficiency or renal tubular dysfunction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0009567	mitotic nondisjuction	"failure of sister-chromatids to separate to the cell poles at anaphase" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0009635	enlarged popliteal lymph nodes	"increased size of the lymph nodes which drain the legs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1.1(DUX4)Plj}/Gt(ROSA)26Sor⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * C57BL/6
MP:0009759	abnormal hair follicle bulge	"an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0009794	sebaceous gland hyperplasia	"overdevelopment and increased size of the sebum secreting glands of the hair shaft, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fto^tm1.1Rdc/Fto^tm1.1Rdc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsmce2^tm2.1Ofc/Nsmce2^tm2.1Ofc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fto^tm1.1Rdc/Fto^tm1.1Rdc,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0010401	increased skeletal muscle glycogen level	"greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0010664	abnormal vitelline artery morphology	"any structural anomaly of the paired arteries that carry blood to the yolk sac from the dorsal aorta; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cnp^tm1(cre)Kan/Cnp⁺,Tfam^tm1Lrsn/Tfam^tm1Lrsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010862	decreased respiratory mucosa goblet cell number	"reduced number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0010872	increased trabecular bone mass	"greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0010873	decreased trabecular bone mass	"reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdk7^{Gt(D032B11)1.1Wrst}/Cdk7^{Gt(D032B11)1.1Wrst},Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvPas * 129S2/SvPas * C57BL/6 * SJL
MP:0010897	abnormal bronchiole epithelium morphology	"any structural anomaly of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0010901	abnormal pulmonary alveolar parenchyma morphology	"any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0010924	abnormal osteoid morphology	"any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0010954	abnormal cellular respiration	"anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]	Show Allelic Composition: Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2⁺ Genetic Background: C57BL/6-Tcf7l2^{tm1a(EUCOMM)Wtsi}
MP:0010965	decreased compact bone volume		Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0011167	abnormal adipose tissue development	"anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]	Show Allelic Composition: Phf2^tm1.2Yima/Phf2^tm1.2Yima,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL
MP:0011182	decreased hematopoietic cell number	"fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]	Show Allelic Composition: Kitl^tm2.1Sjm/Kitl^tm2.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL
MP:0011346	renal tubule atrophy	"acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0011363	renal glomerulus atrophy	"acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: St14^Gt(XM184)Byg/St14⁺ Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0011521	decreased placental labyrinth size	"reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]	Show Allelic Composition: Cnp^tm1(cre)Kan/Cnp⁺,Tfam^tm1Lrsn/Tfam^tm1Lrsn Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011629	decreased mitochondria number	"fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0011635	abnormal mitochondrial crista morphology	"Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]	Show Allelic Composition: Col1a1^{tm3(CAG-IDH2R140Q)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0011643	abnormal tendon collagen fibril morphology	"any structural anomaly of the connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0013288	premature acrosome reaction	"spontaneous initiation of the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs, occurring prior to encountering conditions that induce sperm capacitation" [MGI:smb]	Show Allelic Composition: Apc^Min/Apc⁺,Spata18^tm1.2Hifa/Spata18⁺ Genetic Background: involves: C57BL/6J
MP:0013624	decreased femur compact bone thickness	"reduced width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0013626	decreased femur yield load	"decrease in load (N) on the femur at which elastic deformation ends" [MGI:jwhite]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0013630	increased bone trabecular spacing	"increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0013633	decreased femur maximal load	"decrease in the maximal load (N) sustained by the femur" [MGI:jwhite]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0013638	decreased femur stiffness	"decrease in material stiffness (N/mm) during elastic deformation in the femur" [MGI:jwhite]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0013646	decreased energy dissipated prior to femur fracture	"decrease in the fraction of total energy dissapated prior to ultimate material failure (high energy fracture) by the femur" [MGI:jwhite]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0013941	abnormal enthesis morphology	"any structural anomaly of the connective tissue between tendon and bone insertion sites; the area which acts to transmit tensile load from soft tissues to bone; they may be of the dense fibrous connective tissue or fibrocartilage type; fibrous entheses attach directly to bone or periosteum primarily via fibrous tissue, and fibrocartilaginous entheses attach to bone through a transitional layer of fibrocartilage from the fibrous tendon tissue" [PMID:25489552]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0014046	abnormal mitophagy	"any anomaly in the autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions" [MGI:Anna, PMID:22743996]	Show Allelic Composition: Appl1^tm1.2Test/Appl1^tm1.2Test,Appl2^tm1.1Test/Appl2^tm1.1Test Genetic Background: involves: 129X1/SvJ
MP:0014071	increased cardiac muscle glycogen level	"greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [MGI:Anna]	Show Allelic Composition: Col1a1^{tm2(CAG-IDH2R172K)Kkw}/Col1a1⁺,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background:* involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6
MP:0020010	decreased bone mineral density of femur	"reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0020039	increased bone ossification	"increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0020254	decreased collagen level	"decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0020344	abnormal susceptibility to injury induced morbidity/mortality	"differences from the expected moribund state caused by trauma, especially that by physical means" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0 Genetic Background: involves: C57BL/6
MP:0030484	abnormal osteocyte lacuna morphology	"any structural anomaly of the small cavity within the bone matrix that is occupied by an osteocyte cell body, and from which slender canaliculi radiate and penetrate the adjacent lamellae to anastomose with the canaliculi of neighboring lacunae, thus forming a system of cavities interconnected by minute canals" [https://medical-dictionary.thefreedictionary.com/osteocyte+lacuna]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
MP:0030487	abnormal osteocyte dendritic process morphology	"any structural anomaly of the long, slender cytoplasmic processes by which mature osteocytes communicate with one another, receive mechanosensory signals and participate in the regulation of bone turnover; these processes radiate from the osteocyte cell body, run along narrow canaliculi, and are linked to other neighboring osteocytes processes by gap junctions, as well as to cytoplasmic processes of osteoblasts and bone lining cells on the bone surface" [https://www.hindawi.com/journals/bmri/2015/421746/, PMID:24419319]	Show Allelic Composition: Bmp1^tm1.1Dgr/Bmp1^tm1.1Dgr,Tll1^tm2.1Dgr/Tll1^tm2.1Dgr,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * SJL

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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