ENSMUSG00000034617


Mus musculus

Features
Gene ID: ENSMUSG00000034617
  
Biological name :Mtrr
  
Synonyms : 5-methyltetrahydrofolate-homocysteine methyltransferase reductase / Mtrr
  
Possible biological names infered from orthology : Q9UBK8
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B3
Gene start: 68560780
Gene end: 68582149
  
Corresponding Affymetrix probe sets: 10410393 (MoGene1.0st)   1452110_at (Mouse Genome 430 2.0 Array)   1458093_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039810
Ensembl peptide - ENSMUSP00000152884
Ensembl peptide - ENSMUSP00000152837
Ensembl peptide - ENSMUSP00000152659
Ensembl peptide - ENSMUSP00000152593
Ensembl peptide - ENSMUSP00000152561
Ensembl peptide - ENSMUSP00000152387
NCBI entrez gene - 210009     See in Manteia.
MGI - MGI:1891037
RefSeq - XM_006517182
RefSeq - NM_001308475
RefSeq - NM_172480
RefSeq - XM_006517179
RefSeq - XM_006517181
RefSeq Peptide - NP_766068
RefSeq Peptide - NP_001295404
swissprot - A0A1Y7VKD9
swissprot - A0A1Y7VKC5
swissprot - A0A1Y7VJV6
swissprot - A0A1Y7VLV0
swissprot - A0A0R4J0G9
swissprot - A0A1Y7VM78
Ensembl - ENSMUSG00000034617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtrrENSDARG00000045398Danio rerio
 MTRRENSGALG00000039424Gallus gallus
 MTRRENSG00000124275Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ndor1 / A2AI05 / NADPH-dependent diflavin oxidoreductase 1 / Q9UHB4*ENSMUSG0000000647124
AL732309.2 / NDOR1* / Q9UHB4* / NADPH dependent diflavin oxidoreductase 1*ENSMUSG0000011507420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029039  Flavoprotein-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009086 methionine biosynthetic process IEA
 biological_processGO:0043418 homocysteine catabolic process IEA
 biological_processGO:0046655 folic acid metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1904042 negative regulation of cystathionine beta-synthase activity IEA
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor IEA
 molecular_functionGO:0030586 [methionine synthase] reductase activity IEA
 molecular_functionGO:0050444 aquacobalamin reductase (NADPH) activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0070402 NADPH binding IEA
 molecular_functionGO:0071949 FAD binding IEA


Pathways (from Reactome)
Pathway description
Methylation
Sulfur amino acid metabolism
Cobalamin (Cbl, vitamin B12) transport and metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic Background: B6.129P2-MtrrGt(XG334)Byg

 MP:0006076 abnormal circulating homocysteine level "aberrant concentration in the blood of this amino acid" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic Background: B6.129P2-MtrrGt(XG334)Byg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr