ENSMUSG00000006675


Mus musculus

Features
Gene ID: ENSMUSG00000006675
  
Biological name :P4htm
  
Synonyms : P4htm / prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) / Q8BG58
  
Possible biological names infered from orthology : prolyl 4-hydroxylase, transmembrane / Q9NXG6
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F2
Gene start: 108578862
Gene end: 108597667
  
Corresponding Affymetrix probe sets: 10596940 (MoGene1.0st)   1428211_at (Mouse Genome 430 2.0 Array)   1459807_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141843
Ensembl peptide - ENSMUSP00000141993
Ensembl peptide - ENSMUSP00000006853
NCBI entrez gene - 74443     See in Manteia.
MGI - MGI:1921693
RefSeq - NM_028944
RefSeq - XM_011242914
RefSeq Peptide - NP_083220
swissprot - A0A0A6YXH5
swissprot - Q2M2M8
swissprot - Q8BG58
swissprot - A0A0A6YX56
Ensembl - ENSMUSG00000006675
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p4htmENSDARG00000075209Danio rerio
 P4HTMENSGALG00000006937Gallus gallus
 P4HTMENSG00000178467Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045646 regulation of erythrocyte differentiation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg,P4htmtm1Jomy/P4htmtm1Jomy
Genetic Background: Not Specified

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Apctm1Rsmi/Apctm1Rsmi,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg,P4htmtm1Jomy/P4htmtm1Jomy
Genetic Background: Not Specified

 MP:0011286 decreased circulating erythropoietin level "reduced blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Egln1Gt(RRG405)Byg/Egln1Gt(RRG405)Byg,P4htmtm1Jomy/P4htmtm1Jomy
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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