ENSMUSG00000006764


Mus musculus

Features
Gene ID: ENSMUSG00000006764
  
Biological name :Tph2
  
Synonyms : Q8CGV2 / Tph2 / Tryptophan 5-hydroxylase 2
  
Possible biological names infered from orthology : Q8IWU9 / tryptophan hydroxylase 2
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 115078641
Gene end: 115185022
  
Corresponding Affymetrix probe sets: 10372443 (MoGene1.0st)   1435314_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006949
NCBI entrez gene - 216343     See in Manteia.
MGI - MGI:2651811
RefSeq - NM_173391
RefSeq Peptide - NP_775567
swissprot - Q8CGV2
Ensembl - ENSMUSG00000006764
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tph2ENSDARG00000057239Danio rerio
 TPH2ENSGALG00000010198Gallus gallus
 TPH2ENSG00000139287Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tph1 / P17532 / tryptophan hydroxylase 1 / P17752*ENSMUSG0000004004662
Pah / P16331 / Phenylalanine-4-hydroxylase / P00439* / phenylalanine hydroxylase*ENSMUSG0000002005151
Th / P24529 / tyrosine hydroxylase / P07101*ENSMUSG0000000021447


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005963  Tryptophan 5-monooxygenase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal
 IPR036329  Aromatic amino acid monoxygenase, C-terminal domain superfamily
 IPR036951  Aromatic amino acid hydroxylase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006587 serotonin biosynthetic process from tryptophan IC
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0042427 serotonin biosynthetic process IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071285 cellular response to lithium ion IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004510 tryptophan 5-monooxygenase activity IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: FVB.129P2-Tph2tm1Bdr

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Tph2tm1Pasq/Tph2tm1Pasq
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2tm1Pasq

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: FVB.129P2-Tph2tm1Bdr

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tph2tm2.2Pasq/Tph2tm2.2Pasq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: FVB.129P2-Tph2tm1Bdr

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Ppp1r13btm1Suda/Ppp1r13btm1Suda,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: various

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001356 increased aggression towards females "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward female mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Ppp1r13btm1Suda/Ppp1r13btm1Suda,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: various

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001375 abnormal mating preference "deviation from the usual preference of a male to initiate sexual contact with a receptive female; usually refers to males that initiate sexual behavior with males and females indiscriminately" [J:76339]
Show

Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Tph2tm1Mscl/Tph2tm1Mscl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: FVB.129P2-Tph2tm1Bdr

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tph2tm1Pasq/Tph2tm1Pasq
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2tm1Pasq

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: FVB.129P2-Tph2tm1Bdr

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Tph2tm1Mscl/Tph2tm1Mscl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003064 decreased coping response "reduced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tph2tm1Mca/Tph2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003877 abnormal serotonergic neuron morphology "malformation or absence of the neurons that secrete serotonin" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54240]
Show

Allelic Composition: Otcspf-ash/Otc+
Genetic Background: involves: C57BL/6

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: FVB.129P2-Tph2tm1Bdr

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sdc1tm1Cma/Sdc1tm1Cma
Genetic Background: B6.Cg-Sdc1tm1Cma

Allelic Composition: Tph2Arg447/Tph2Arg447
Genetic Background: DBA/2J

Allelic Composition: Tph2Pro447/Tph2Pro447
Genetic Background: 129X1/SvJ

Allelic Composition: Tph2Pro447/Tph2Pro447
Genetic Background: C57BL/6J

Allelic Composition: Tph2tm1Mca/Tph2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tph2tm1Mca/Tph2tm1Mca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: FVB.129P2-Tph2tm1Bdr

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005655 increased aggression "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0006276 abnormal autonomic nervous system physiology "anomaly in the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controling involuntary bodily functions" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008845 abnormal paraventricular hypothalamic nucleus morphology "any structural anomaly of a group of magnocellular neurons located in the periventricular zone of the anterior half of the hypothalamus" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tph2tm1Pasq/Tph2tm1Pasq
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2tm1Pasq

 MP:0008847 abnormal suprachiasmatic nucleus morphology "any structural anomaly of an ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the optic chiasm; it receives input from the retina and influences neuroendocrine function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.317.357.342.625]
Show

Allelic Composition: Tph2tm1Pasq/Tph2tm1Pasq
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2tm1Pasq

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Tph2tm1Mscl/Tph2tm1Mscl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Allelic Composition: Tph2tm1Dmkh/Tph2tm1Dmkh
Genetic Background: involves: C57BL/6

Allelic Composition: Tph2tm2.2Pasq/Tph2tm2.2Pasq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tph2tm2.1Pasq/Tph2tm2.2Pasq,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011016 increased core body temperature "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tph2tm1Dmkh/Tph2tm1Dmkh
Genetic Background: involves: C57BL/6

 MP:0011021 abnormal circadian regulation of heart rate "anomaly in the process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours" [GO:0003053]
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Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: FVB.129P2-Tph2tm1Bdr

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011022 abnormal circadian regulation of systemic arterial blood pressure "any anomaly in the process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours" [GO:0003052]
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Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: FVB.129P2-Tph2tm1Bdr

Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Tph2tm1Bdr/Tph2tm1Bdr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tph2tm1Pasq/Tph2tm1Pasq
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2tm1Pasq

Allelic Composition: Tph2tm2.2Pasq/Tph2tm2.2Pasq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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