ENSMUSG00000040046


Mus musculus

Features
Gene ID: ENSMUSG00000040046
  
Biological name :Tph1
  
Synonyms : P17532 / Tph1 / tryptophan hydroxylase 1
  
Possible biological names infered from orthology : P17752
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 46644641
Gene end: 46672537
  
Corresponding Affymetrix probe sets: 10563570 (MoGene1.0st)   1419524_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103296
Ensembl peptide - ENSMUSP00000128727
Ensembl peptide - ENSMUSP00000132489
Ensembl peptide - ENSMUSP00000037752
Ensembl peptide - ENSMUSP00000128107
NCBI entrez gene - 21990     See in Manteia.
MGI - MGI:98796
RefSeq - XM_011250846
RefSeq - NM_001136084
RefSeq - NM_001276372
RefSeq - NM_009414
RefSeq Peptide - NP_001263301
RefSeq Peptide - NP_033440
RefSeq Peptide - NP_001129556
swissprot - Q3TZH2
swissprot - E9Q060
swissprot - Q3UK52
swissprot - P17532
swissprot - F7BYX2
Ensembl - ENSMUSG00000040046
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tph1aENSDARG00000029432Danio rerio
 tph1bENSDARG00000036082Danio rerio
 TPH1ENSGALG00000006236Gallus gallus
 TPH1ENSG00000129167Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tph2 / Q8CGV2 / Tryptophan 5-hydroxylase 2 / Q8IWU9* / tryptophan hydroxylase 2*ENSMUSG0000000676468
Pah / P16331 / Phenylalanine-4-hydroxylase / P00439* / phenylalanine hydroxylase*ENSMUSG0000002005154
Th / P24529 / tyrosine hydroxylase / P07101*ENSMUSG0000000021449


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005963  Tryptophan 5-monooxygenase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal
 IPR036329  Aromatic amino acid monoxygenase, C-terminal domain superfamily
 IPR036951  Aromatic amino acid hydroxylase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042427 serotonin biosynthetic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0046849 bone remodeling IGI
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060749 mammary gland alveolus development IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004510 tryptophan 5-monooxygenase activity IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0002899 fatigue "easily exhausted due to mental or physical exertion" [hdene:Howard Dene , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0030438 increased osteoblast proliferation "increase in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
Show

Allelic Composition: Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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