ENSDARG00000036082


Danio rerio

Features
Gene ID: ENSDARG00000036082
  
Biological name :tph1b
  
Synonyms : tph1b / tryptophan hydroxylase 1b
  
Possible biological names infered from orthology : P17532 / P17752 / TPH1 / tryptophan hydroxylase 1
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 33106332
Gene end: 33114884
  
Corresponding Affymetrix probe sets: Dr.15819.1.A1_at (Zebrafish Array)   Dr.17776.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000052384
NCBI entrez gene - 415103     See in Manteia.
RefSeq - NM_001001843
RefSeq Peptide - NP_001001843
swissprot - Q6IWP4
ZFIN ID - ZDB-GENE-030805-6
Ensembl - ENSDARG00000036082
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TPH1ENSGALG00000006236Gallus gallus
 TPH1ENSG00000129167Homo sapiens
 Tph1ENSMUSG00000040046Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tph1a / tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a / TPH1* / P17752* / P17532* / tryptophan hydroxylase 1*ENSDARG0000002943281
tph2 / tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) / Q8IWU9* / Q8CGV2* / tryptophan hydroxylase 2* / Tryptophan 5-hydroxylase 2 *ENSDARG0000005723966
pah / phenylalanine hydroxylase / P00439* / P16331* / Phenylalanine-4-hydroxylase *ENSDARG0000002014352
th2 / tyrosine hydroxylase 2ENSDARG0000003838446
th / tyrosine hydroxylase / P07101* / P24529*ENSDARG0000003062145


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005963  Tryptophan 5-monooxygenase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0042427 serotonin biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IMP
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004510 tryptophan 5-monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism decreased weight , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased distribution , abnormal
hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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