ENSDARG00000038384


Danio rerio

Features
Gene ID: ENSDARG00000038384
  
Biological name :th2
  
Synonyms : th2 / tyrosine hydroxylase 2
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 17380578
Gene end: 17391091
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000056001
NCBI entrez gene - 414844     See in Manteia.
RefSeq - NM_001001829
RefSeq Peptide - NP_001001829
swissprot - Q1LWZ5
ZFIN ID - ZDB-GENE-050201-1
Ensembl - ENSDARG00000038384
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000019300Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
th / tyrosine hydroxylase / P07101* / P24529*ENSDARG0000003062162
tph1a / tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a / TPH1* / P17752* / P17532* / tryptophan hydroxylase 1*ENSDARG0000002943248
pah / phenylalanine hydroxylase / P00439* / P16331* / Phenylalanine-4-hydroxylase *ENSDARG0000002014348
tph2 / tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) / Q8IWU9* / Q8CGV2* / tryptophan hydroxylase 2* / Tryptophan 5-hydroxylase 2 *ENSDARG0000005723946
tph1b / tryptophan hydroxylase 1b / TPH1* / P17752* / P17532* / tryptophan hydroxylase 1*ENSDARG0000003608246


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0042416 dopamine biosynthetic process IMP
 biological_processGO:0042427 serotonin biosynthetic process IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004510 tryptophan 5-monooxygenase activity IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000634 caudal hypothalamic zone caudal hypothalamic zone neuron increased amount , abnormal
caudal hypothalamic zone neuron increased distribution , abnormal
Show

 ZFA:0001114 head head decreased amount , abnormal
head dopamine decreased amount , abnormal
head histamine increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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