ENSDARG00000020143


Danio rerio

Features
Gene ID: ENSDARG00000020143
  
Biological name :pah
  
Synonyms : pah / phenylalanine hydroxylase
  
Possible biological names infered from orthology : P00439 / P16331 / Phenylalanine-4-hydroxylase
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 17391680
Gene end: 17409533
  
Corresponding Affymetrix probe sets: Dr.4171.1.A1_at (Zebrafish Array)   NM_200551_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000012808
NCBI entrez gene - 378962     See in Manteia.
RefSeq - NM_200551
RefSeq Peptide - NP_956845
swissprot - Q7SYH6
ZFIN ID - ZDB-GENE-031006-2
Ensembl - ENSDARG00000020143
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAHENSGALG00000012754Gallus gallus
 PAHENSG00000171759Homo sapiens
 PahENSMUSG00000020051Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tph1b / tryptophan hydroxylase 1b / TPH1* / P17752* / P17532* / tryptophan hydroxylase 1*ENSDARG0000003608256
tph1a / tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a / TPH1* / P17752* / P17532* / tryptophan hydroxylase 1*ENSDARG0000002943256
tph2 / tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) / Q8IWU9* / Q8CGV2* / tryptophan hydroxylase 2* / Tryptophan 5-hydroxylase 2 *ENSDARG0000005723954
th / tyrosine hydroxylase / P07101* / P24529*ENSDARG0000003062151
th2 / tyrosine hydroxylase 2ENSDARG0000003838450


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005961  Phenylalanine-4-hydroxylase, tetrameric form
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006559 L-phenylalanine catabolic process IEA
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071391 cellular response to estrogen stimulus IDA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004505 phenylalanine 4-monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Phenylalanine and tyrosine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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