ENSDARG00000030621


Danio rerio

Features
Gene ID: ENSDARG00000030621
  
Biological name :th
  
Synonyms : th / tyrosine hydroxylase
  
Possible biological names infered from orthology : P07101 / P24529
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 24055341
Gene end: 24074500
  
Corresponding Affymetrix probe sets: Dr.21022.1.A1_at (Zebrafish Array)   Dr.21022.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000040409
NCBI entrez gene - 30384     See in Manteia.
RefSeq - NM_131149
RefSeq Peptide - NP_571224
swissprot - B3DJW5
ZFIN ID - ZDB-GENE-990621-5
Ensembl - ENSDARG00000030621
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 THENSGALG00000029648Gallus gallus
 THENSG00000180176Homo sapiens
 ThENSMUSG00000000214Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
th2 / tyrosine hydroxylase 2ENSDARG0000003838459
pah / phenylalanine hydroxylase / P00439* / P16331* / Phenylalanine-4-hydroxylase *ENSDARG0000002014347
tph2 / tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) / Q8IWU9* / Q8CGV2* / tryptophan hydroxylase 2* / Tryptophan 5-hydroxylase 2 *ENSDARG0000005723946
tph1a / tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a / TPH1* / P17752* / P17532* / tryptophan hydroxylase 1*ENSDARG0000002943246
tph1b / tryptophan hydroxylase 1b / TPH1* / P17752* / P17532* / tryptophan hydroxylase 1*ENSDARG0000003608244


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR005962  Tyrosine 3-monooxygenase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal
 IPR021164  Tyrosine hydroxylase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0042416 dopamine biosynthetic process IMP
 biological_processGO:0042423 catecholamine biosynthetic process IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004511 tyrosine 3-monooxygenase activity IMP
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Catecholamine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism increased amount , abnormal
Show

 ZFA:0001114 head head decreased amount , abnormal
head dopamine decreased amount , abnormal
head (R)-adrenaline decreased amount , abnormal
head noradrenaline decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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