ENSG00000129167


Homo sapiens

Features
Gene ID: ENSG00000129167
  
Biological name :TPH1
  
Synonyms : P17752 / TPH1 / tryptophan hydroxylase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.1
Gene start: 18017564
Gene end: 18042426
  
Corresponding Affymetrix probe sets: 1553859_at (Human Genome U133 Plus 2.0 Array)   214601_at (Human Genome U133 Plus 2.0 Array)   231626_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000250018
Ensembl peptide - ENSP00000436081
Ensembl peptide - ENSP00000403831
NCBI entrez gene - 7166     See in Manteia.
OMIM - 191060
RefSeq - NM_004179
RefSeq Peptide - NP_004170
swissprot - E9PR49
swissprot - E7EMX4
swissprot - P17752
Ensembl - ENSG00000129167
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tph1aENSDARG00000029432Danio rerio
 tph1bENSDARG00000036082Danio rerio
 TPH1ENSGALG00000006236Gallus gallus
 Tph1ENSMUSG00000040046Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPH2 / Q8IWU9 / tryptophan hydroxylase 2ENSG0000013928771
PAH / P00439 / phenylalanine hydroxylaseENSG0000017175955
TH / P07101 / tyrosine hydroxylaseENSG0000018017649


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005963  Tryptophan 5-monooxygenase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal
 IPR036329  Aromatic amino acid monoxygenase, C-terminal domain superfamily
 IPR036951  Aromatic amino acid hydroxylase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042427 serotonin biosynthetic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0046219 indolalkylamine biosynthetic process TAS
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004510 tryptophan 5-monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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