ENSG00000139287


Homo sapiens

Features
Gene ID: ENSG00000139287
  
Biological name :TPH2
  
Synonyms : Q8IWU9 / TPH2 / tryptophan hydroxylase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q21.1
Gene start: 71938846
Gene end: 72186618
  
Corresponding Affymetrix probe sets: 1555332_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000329093
NCBI entrez gene - 121278     See in Manteia.
OMIM - 607478
RefSeq - NM_173353
RefSeq Peptide - NP_775489
swissprot - Q8IWU9
Ensembl - ENSG00000139287
  
Related genetic diseases (OMIM): 608516 - {Unipolar depression, susceptibility to}, 608516
  613003 - {Attention deficit-hyperactivity disorder, susceptibility to, 7}, 613003
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tph2ENSDARG00000057239Danio rerio
 TPH2ENSGALG00000010198Gallus gallus
 Tph2ENSMUSG00000006764Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPH1 / P17752 / tryptophan hydroxylase 1ENSG0000012916765
PAH / P00439 / phenylalanine hydroxylaseENSG0000017175951
TH / P07101 / tyrosine hydroxylaseENSG0000018017646


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005963  Tryptophan 5-monooxygenase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal
 IPR036329  Aromatic amino acid monoxygenase, C-terminal domain superfamily
 IPR036951  Aromatic amino acid hydroxylase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0042427 serotonin biosynthetic process IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0046219 indolalkylamine biosynthetic process TAS
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071285 cellular response to lithium ion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004510 tryptophan 5-monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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