ENSMUSG00000006800


Mus musculus

Features
Gene ID: ENSMUSG00000006800
  
Biological name :Sulf2
  
Synonyms : Mus musculus sulfatase 2 (Sulf2), transcript variant 4, mRNA. / Q8CFG0 / Sulf2
  
Possible biological names infered from orthology : Q8IWU5 / sulfatase 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 166073089
Gene end: 166155663
  
Corresponding Affymetrix probe sets: 10489759 (MoGene1.0st)   1430388_a_at (Mouse Genome 430 2.0 Array)   1442408_at (Mouse Genome 430 2.0 Array)   1447602_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154557
Ensembl peptide - ENSMUSP00000104872
Ensembl peptide - ENSMUSP00000154315
Ensembl peptide - ENSMUSP00000085405
Ensembl peptide - ENSMUSP00000154724
NCBI entrez gene - 72043     See in Manteia.
MGI - MGI:1919293
RefSeq - XM_017319268
RefSeq - NM_001252578
RefSeq - NM_001252579
RefSeq - NM_001355619
RefSeq - NM_028072
RefSeq - XM_006500209
RefSeq - XM_006500211
RefSeq Peptide - NP_082348
RefSeq Peptide - NP_001239507
RefSeq Peptide - NP_001239508
RefSeq Peptide - NP_001342548
swissprot - Q8CFG0
Ensembl - ENSMUSG00000006800
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sulf2bENSDARG00000013838Danio rerio
 SULF2ENSGALG00000004593Gallus gallus
 SULF2ENSG00000196562Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sulf1 / Q8K007 / Extracellular sulfatase Sulf-1 / Q8IWU6* / sulfatase 1*ENSMUSG0000001691864
Gns / Q8BFR4 / glucosamine (N-acetyl)-6-sulfatase / P15586*ENSMUSG0000003470726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000917  Sulfatase, N-terminal
 IPR014615  Extracellular sulfatase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR024607  Sulfatase, conserved site
 IPR024609  Extracellular sulfatase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IGI
 biological_processGO:0002063 chondrocyte development IMP
 biological_processGO:0003094 glomerular filtration IGI
 biological_processGO:0006790 sulfur compound metabolic process ISO
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IGI
 biological_processGO:0014846 esophagus smooth muscle contraction IGI
 biological_processGO:0030177 positive regulation of Wnt signaling pathway ISO
 biological_processGO:0030201 heparan sulfate proteoglycan metabolic process IMP
 biological_processGO:0032836 glomerular basement membrane development IGI
 biological_processGO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway IDA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0048706 embryonic skeletal system development IGI
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060348 bone development IGI
 biological_processGO:0060384 innervation IGI
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0097421 liver regeneration IMP
 biological_processGO:2000345 regulation of hepatocyte proliferation IMP
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005795 Golgi stack IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004065 arylsulfatase activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008449 N-acetylglucosamine-6-sulfatase activity ISO
 molecular_functionGO:0008484 sulfuric ester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Chg/Shh+,Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shhtm1Chg/Shh+,Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10

 MP:0000106 abnormal basisphenoid bone morphology "malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ltbrtm1.1Thhe/Ltbrtm1.1Thhe,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Sulf1tm1Mmas/Sulf1tm1Mmas,Sulf2tm1Mmas/Sulf2tm1Mmas
Genetic Background: B6N.129P2-Sulf1tm1Mmas Sulf2tm1Mmas

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000740 impaired smooth muscle contractility "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001044 abnormal enteric nervous system morphology "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Sall1tm3Ryn/Sall1tm3Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sall1tm3Ryn/Sall1tm3Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: B6.Cg-Sulf2tm1.1Cpe

Allelic Composition: Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Sall1tm3Ryn/Sall1tm3Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Sulf2Gt(XST155)Byg/Sulf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Shhtm1Chg/Shh+,Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Shhtm1Chg/Shh+,Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: B6.Cg-Sulf2tm1.1Cpe

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Sall1tm3Ryn/Sall1tm3Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Sall1tm3Ryn/Sall1tm3Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Sall1tm3Ryn/Sall1tm3Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Sall1tm3Ryn/Sall1tm3Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Cacng2stg/Cacng2stg
Genetic Background: B6C3Fe a/a-Cacng2stg

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004545 enlarged esophagus "increased size of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: B6.Cg-Sulf2tm1.1Cpe

Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004548 dilated esophagus "an expansion in the lumen volume of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004619 caudal vertebral fusion "the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004622 sacral vertebral fusion "the union of one or more sacral vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004623 thoracic vertebral fusion "the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004687 split vertebrae "any vertebrae or vertebral section that is cleft into two parts " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004831 long incisors "increased length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1+,Sulf2Gt(PST111)Byg/Sulf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sulf1tm1Clrm/Sulf1tm1Clrm,Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Sall1tm3Ryn/Sall1tm3Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ltbrtm1.1Thhe/Ltbrtm1.1Thhe,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Sulf2Gt(XST155)Byg/Sulf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Sall1tm3Ryn/Sall1tm3Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Sulf2tm1Clrm/Sulf2tm1Clrm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012279 wide sternum "an increase in the width of the long flat bone of the chest that articulates with the clavicle and first seven rib pairs" [MGI:anna]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030541 misaligned incisors "abnormal alignment of the upper and lower incisor teeth, usually resulting in malocclusion; in gnawing rodents, where incisors are rootless and grow continually, signs of incisor malocclusion include uneven wear patterns, sloping of the cutting edges, fractured teeth, altered pigmentation, and obvious pathological overgrowth of the incisors" [HP:0011062, https://books.google.com/books?isbn=0323394302, PMID:19622764]
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Allelic Composition: Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg,Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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