ENSMUSG00000034707


Mus musculus

Features
Gene ID: ENSMUSG00000034707
  
Biological name :Gns
  
Synonyms : glucosamine (N-acetyl)-6-sulfatase / Gns / Q8BFR4
  
Possible biological names infered from orthology : P15586
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D2
Gene start: 121365090
Gene end: 121397249
  
Corresponding Affymetrix probe sets: 10366667 (MoGene1.0st)   1433488_x_at (Mouse Genome 430 2.0 Array)   1433546_at (Mouse Genome 430 2.0 Array)   1446861_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043167
Ensembl peptide - ENSMUSP00000152016
Ensembl peptide - ENSMUSP00000151684
Ensembl peptide - ENSMUSP00000151434
NCBI entrez gene - 75612     See in Manteia.
MGI - MGI:1922862
RefSeq - NM_029364
RefSeq Peptide - NP_083640
swissprot - A0A1W2P7K3
swissprot - A0A1W2P6W9
swissprot - A0A1W2P8D3
swissprot - Q8BFR4
Ensembl - ENSMUSG00000034707
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnsaENSDARG00000023766Danio rerio
 GNSENSGALG00000009856Gallus gallus
 GNSENSG00000135677Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sulf2 / Q8CFG0 / Mus musculus sulfatase 2 (Sulf2), transcript variant 4, mRNA. / Q8IWU5* / sulfatase 2*ENSMUSG0000000680042
Sulf1 / Q8K007 / Extracellular sulfatase Sulf-1 / Q8IWU6* / sulfatase 1*ENSMUSG0000001691840


Protein motifs (from Interpro)
Interpro ID Name
 IPR000917  Sulfatase, N-terminal
 IPR012251  N-acetylglucosamine-6-sulfatase
 IPR015981  N-acetylglucosamine-6-sulfatase, metazoan
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR024607  Sulfatase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030203 glycosaminoglycan metabolic process IEA
 cellular_componentGO:0005764 lysosome IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008449 N-acetylglucosamine-6-sulfatase activity IEA
 molecular_functionGO:0008484 sulfuric ester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Keratan sulfate degradation
Lysosome Vesicle Biogenesis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Il15tm1Imx/Il15tm1Imx,X/Yaa
Genetic Background: BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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