ENSMUSG00000007877


Mus musculus

Features
Gene ID: ENSMUSG00000007877
  
Biological name :Tcap
  
Synonyms : O70548 / Tcap / titin-cap
  
Possible biological names infered from orthology : O15273
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98383811
Gene end: 98384953
  
Corresponding Affymetrix probe sets: 10380887 (MoGene1.0st)   1423145_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008021
NCBI entrez gene - 21393     See in Manteia.
MGI - MGI:1330233
RefSeq - NM_011540
RefSeq Peptide - NP_035670
swissprot - O70548
swissprot - Q545G3
Ensembl - ENSMUSG00000007877
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcapENSDARG00000007344Danio rerio
 TCAPENSG00000173991Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015667  Telethonin
 IPR023111  Titin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IEP
 biological_processGO:0003009 skeletal muscle contraction IEA
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0007512 adult heart development IEP
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:0030240 skeletal muscle thin filament assembly IEA
 biological_processGO:0030241 skeletal muscle myosin thick filament assembly IEA
 biological_processGO:0030916 otic vesicle formation IEP
 biological_processGO:0035995 detection of muscle stretch IEA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0048739 cardiac muscle fiber development IEA
 biological_processGO:0048769 sarcomerogenesis IEA
 biological_processGO:0055003 cardiac myofibril assembly IEA
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0031674 I band IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008307 structural constituent of muscle IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0031432 titin binding IEA
 molecular_functionGO:0036122 BMP binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0051373 FATZ binding IEA
 molecular_functionGO:0070080 titin Z domain binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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