ENSMUSG00000009394


Mus musculus

Features
Gene ID: ENSMUSG00000009394
  
Biological name :Syn2
  
Synonyms : Q64332 / Syn2 / Synapsin-2
  
Possible biological names infered from orthology : synapsin II
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 115134902
Gene end: 115282006
  
Corresponding Affymetrix probe sets: 10540880 (MoGene1.0st)   1428460_at (Mouse Genome 430 2.0 Array)   1435511_at (Mouse Genome 430 2.0 Array)   1440762_at (Mouse Genome 430 2.0 Array)   1449030_at (Mouse Genome 430 2.0 Array)   1458105_at (Mouse Genome 430 2.0 Array)   1460230_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009538
Ensembl peptide - ENSMUSP00000133121
Ensembl peptide - ENSMUSP00000144921
NCBI entrez gene - 20965     See in Manteia.
MGI - MGI:103020
RefSeq - NM_001326560
RefSeq - NM_001111015
RefSeq - NM_013681
RefSeq Peptide - NP_001104485
RefSeq Peptide - NP_001313489
RefSeq Peptide - NP_038709
swissprot - Q64332
Ensembl - ENSMUSG00000009394
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syn2aENSDARG00000045945Danio rerio
 syn2bENSDARG00000101054Danio rerio
 SYN2ENSGALG00000004955Gallus gallus
 SYN2ENSG00000157152Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syn1 / O88935 / Synapsin-1 / P17600* / synapsin I*ENSMUSG0000003721762
Syn3 / Q8JZP2 / Synapsin-3 / O14994* / synapsin III*ENSMUSG0000005960256


Protein motifs (from Interpro)
Interpro ID Name
 IPR001359  Synapsin
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR019735  Synapsin, conserved site
 IPR019736  Synapsin, phosphorylation site
 IPR020897  Synapsin, pre-ATP-grasp domain
 IPR020898  Synapsin, ATP-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007269 neurotransmitter secretion IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IDA
 cellular_componentGO:0031201 SNARE complex IDA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0046983 protein dimerization activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Syn1tm1Sud/Syn1tm1Sud,Syn2tm1Sud/Syn2tm1Sud
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rspo2ftls/Rspo2+
Genetic Background: involves: FVB/N

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Rspo2ftls/Rspo2+
Genetic Background: involves: FVB/N

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rspo2ftls/Rspo2+
Genetic Background: involves: FVB/N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0002800 abnormal short-term recognition memory "defects in the short-term memory for objects is established during the first few minutes after training" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Syn1tm1Sud/Syn1tm1Sud,Syn2tm1Sud/Syn2tm1Sud
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Syn1tm1Sud/Syn1tm1Sud,Syn2tm1Sud/Syn2tm1Sud
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002924 delayed CNS synapse formation "increase in time required to complete the process of generating connections between an axon and effector tissue or neuron " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0012006 abnormal hippocampus physiology "any functional anomaly related to processes in the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [MPD:Molly]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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