ENSMUSG00000059602


Mus musculus

Features
Gene ID: ENSMUSG00000059602
  
Biological name :Syn3
  
Synonyms : Q8JZP2 / Syn3 / Synapsin-3
  
Possible biological names infered from orthology : O14994 / synapsin III
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 86055125
Gene end: 86498896
  
Corresponding Affymetrix probe sets: 10371466 (MoGene1.0st)   1421248_at (Mouse Genome 430 2.0 Array)   1435310_at (Mouse Genome 430 2.0 Array)   1435311_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113408
Ensembl peptide - ENSMUSP00000113720
NCBI entrez gene - 27204     See in Manteia.
MGI - MGI:1351334
RefSeq - XM_011243462
RefSeq - NM_001164495
RefSeq - NM_013722
RefSeq - XM_006513701
RefSeq - XM_006513702
RefSeq - XM_006513704
RefSeq - XM_011243461
RefSeq - XM_006513698
RefSeq - XM_006513699
RefSeq - XM_006513700
RefSeq Peptide - NP_001157967
RefSeq Peptide - NP_038750
swissprot - Q8JZP2
swissprot - D3Z620
Ensembl - ENSMUSG00000059602
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000039889Gallus gallus
 SYN3ENSG00000185666Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syn2 / Q64332 / Synapsin-2 / synapsin II*ENSMUSG0000000939457
Syn1 / O88935 / Synapsin-1 / P17600* / synapsin I*ENSMUSG0000003721755


Protein motifs (from Interpro)
Interpro ID Name
 IPR001359  Synapsin
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR019735  Synapsin, conserved site
 IPR019736  Synapsin, phosphorylation site
 IPR020897  Synapsin, pre-ATP-grasp domain
 IPR020898  Synapsin, ATP-binding domain
 IPR028712  Synapsin-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007269 neurotransmitter secretion IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002946 delayed axon outgrowth "an increased amount of time required for an axon to extend from a neuron cell body and find the target" [J:77048, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002969 impaired social transmission of food preference "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [J:62218]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0003863 decreased aggression towards mice "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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