ENSMUSG00000037217


Mus musculus

Features
Gene ID: ENSMUSG00000037217
  
Biological name :Syn1
  
Synonyms : O88935 / Syn1 / Synapsin-1
  
Possible biological names infered from orthology : P17600 / synapsin I
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.3
Gene start: 20860511
Gene end: 20921004
  
Corresponding Affymetrix probe sets: 10603843 (MoGene1.0st)   1451484_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080568
Ensembl peptide - ENSMUSP00000111002
NCBI entrez gene - 20964     See in Manteia.
MGI - MGI:98460
RefSeq - NM_001110780
RefSeq - NM_013680
RefSeq Peptide - NP_001104250
RefSeq Peptide - NP_038708
swissprot - O88935
Ensembl - ENSMUSG00000037217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syn1ENSDARG00000060368Danio rerio
 SYN1ENSG00000008056Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syn2 / Q64332 / Synapsin-2 / synapsin II*ENSMUSG0000000939451
Syn3 / Q8JZP2 / Synapsin-3 / O14994* / synapsin III*ENSMUSG0000005960245


Protein motifs (from Interpro)
Interpro ID Name
 IPR001359  Synapsin
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR019735  Synapsin, conserved site
 IPR019736  Synapsin, phosphorylation site
 IPR020897  Synapsin, pre-ATP-grasp domain
 IPR020898  Synapsin, ATP-binding domain
 IPR028713  Synapsin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007269 neurotransmitter secretion IMP
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity TAS
 biological_processGO:0097091 synaptic vesicle clustering IMP
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IDA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0098793 presynapse IDA
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0046983 protein dimerization activity TAS
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Syn1tm1Sud/Syn1tm1Sud,Syn2tm1Sud/Syn2tm1Sud
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Syn1tm1Sud/Syn1tm1Sud,Syn2tm1Sud/Syn2tm1Sud
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Syn1tm1Sud/Syn1tm1Sud,Syn2tm1Sud/Syn2tm1Sud
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002924 delayed CNS synapse formation "increase in time required to complete the process of generating connections between an axon and effector tissue or neuron " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tyrp1b/Tyrp1b-3CHLe
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002969 impaired social transmission of food preference "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [J:62218]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrp1b/Tyrp1b-3CHLe
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0004793 abnormal synaptic vesicle clustering "any functional anomaly in the process of accumulation of synaptic vesicles at the active zone of presynaptic membranes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Syn1tm1Noh/Syn1tm1Noh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Syn1tm2Noh/Syn1tm2Noh
Genetic Background: involves: 129S4/SvJae

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

Allelic Composition: Syn1tm1Noh/Syn1tm1Noh
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Syn1tm2Noh/Syn1tm2Noh
Genetic Background: involves: 129S4/SvJae

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: B6J.129P2-Htttm2Detl

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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