Manteia - Molecule gene

ENSMUSG00000010936

Mus musculus

Features

Gene ID:	ENSMUSG00000010936

Biological name :	Vac14

Synonyms :	Q80WQ2 / Vac14 / Vac14 homolog (S. cerevisiae)

Possible biological names infered from orthology :	Q08AM6 / Vac14, PIKFYVE complex component

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	D3
Gene start:	110618585
Gene end:	110720398

Corresponding Affymetrix probe sets:	10575476 (MoGene1.0st) 1416231_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000148440 Ensembl peptide - ENSMUSP00000148548 Ensembl peptide - ENSMUSP00000034190 NCBI entrez gene - 234729 See in Manteia. MGI - MGI:2157980 RefSeq - XM_006530918 RefSeq - XM_006530919 RefSeq - NM_146216 RefSeq Peptide - NP_666328 swissprot - Q80WQ2 swissprot - A0A1D5RLY2 swissprot - A0A1D5RLN5 Ensembl - ENSMUSG00000010936

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
vac14	ENSDARG00000014303	Danio rerio
VAC14	ENSGALG00000002458	Gallus gallus
VAC14	ENSG00000103043	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR011989	Armadillo-like helical
IPR016024	Armadillo-type fold
IPR021841	Vacuolar protein 14 C-terminal Fig4-binding domain
IPR026825	Vacuole morphology and inheritance protein 14
IPR032878	Vacuole morphology and inheritance protein 14, Fab1-binding region

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006661	phosphatidylinositol biosynthetic process	IEA
biological_process	GO:0006970	response to osmotic stress	ISA
biological_process	GO:0042327	positive regulation of phosphorylation	IEA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005774	vacuolar membrane	ISA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0010008	endosome membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0031090	organelle membrane	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
cellular_component	GO:0070772	PAS complex	IEA
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0019209	kinase activator activity	ISA

Pathways (from Reactome)

Pathway description

Synthesis of PIPs at the Golgi membrane

Synthesis of PIPs at the early endosome membrane

Synthesis of PIPs at the late endosome membrane

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000358	abnormal cell content/ morphology	"structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000371	diluted coat color	"a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J Allelic Composition: Vac14^{Gt(RRP155)Byg}/Vac14^ingls Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000819	abnormal olfactory bulb morphology	"malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000832	abnormal thalamus morphology	"malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000837	abnormal hypothalamus morphology	"any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000846	abnormal medulla oblongata	"anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000848	abnormal pons	"malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000897	abnormal midbrain	"malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000904	abnormal superior colliculus	"dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000960	abnormal sensory ganglia morphology	"malformation or absence of a group of sensory neuron cell bodies" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0001092	abnormal trigeminal ganglion morphology	"malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J Allelic Composition: Vac14^{Gt(RRP155)Byg}/Vac14^ingls Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0002183	gliosis	"increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0002654	spongiform encephalopathy	"a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0003105	abnormal heart atrium morphology	"structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0008535	enlarged lateral ventricles	"increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eno2^tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/? Genetic Background: involves: C57BL/6
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J Allelic Composition: Vac14^{Gt(RRP155)Byg}/Vac14^{Gt(RRP155)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Vac14^{Gt(RRP155)Byg}/Vac14^ingls Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
MP:0011380	enlarged brain ventricle	"increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J Allelic Composition: Vac14^{Gt(RRP155)Byg}/Vac14^ingls Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
MP:0012261	increased hindbrain apoptosis	"increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Vac14^{Gt(RRP155)Byg}/Vac14^{Gt(RRP155)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0012503	increased midbrain apoptosis	"increase in the number of cells of the midbrain undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Vac14^{Gt(RRP155)Byg}/Vac14^{Gt(RRP155)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0012504	increased forebrain apoptosis	"increase in the number of cells of the forebrain undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Vac14^{Gt(RRP155)Byg}/Vac14^{Gt(RRP155)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025949	Q9Z1T6 / Pikfyve / phosphoinositide kinase, FYVE type zinc finger containing / Q9Y2I7*	/ complex
ENSMUSG00000038417	Fig4 / Q91WF7 / Polyphosphoinositide phosphatase / Q92562* / FIG4 phosphoinositide 5-phosphatase*	/ complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr