ENSMUSG00000038417


Mus musculus

Features
Gene ID: ENSMUSG00000038417
  
Biological name :Fig4
  
Synonyms : Fig4 / Polyphosphoinositide phosphatase / Q91WF7
  
Possible biological names infered from orthology : FIG4 phosphoinositide 5-phosphatase / Q92562
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B1
Gene start: 41188172
Gene end: 41303260
  
Corresponding Affymetrix probe sets: 10368782 (MoGene1.0st)   1419577_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039598
NCBI entrez gene - 103199     See in Manteia.
MGI - MGI:2143585
RefSeq - NM_133999
RefSeq Peptide - NP_598760
swissprot - Q91WF7
Ensembl - ENSMUSG00000038417
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FIG4ENSDARG00000107912Danio rerio
 FIG4ENSGALG00000015070Gallus gallus
 FIG4ENSG00000112367Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002013  SAC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007033 vacuole organization IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0031642 negative regulation of myelination IMP
 biological_processGO:0032288 myelin assembly IGI
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0046488 phosphatidylinositol metabolic process IMP
 biological_processGO:0048666 neuron development IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034593 phosphatidylinositol bisphosphate phosphatase activity IEA
 molecular_functionGO:0042578 phosphoric ester hydrolase activity IEA
 molecular_functionGO:0043812 phosphatidylinositol-4-phosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dscam2J/Dscam2J
Genetic Background: involves: C3H/HeDiSnJ

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dscam2J/Dscam2J
Genetic Background: involves: C3H/HeDiSnJ

 MP:0000440 domed skull 
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Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fig4plt1/Fig4plt1,Tg(GFAP-Fig4)#Mm/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fig4plt1/Fig4plt1,Tg(GFAP-Fig4)#Mm/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Fig4plt1/Fig4plt1,Tg(Eno2-Fig4)#Mm/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(GFAP-Fig4)#Mm/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)721Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fig4plt1/Fig4plt1,Tg(GFAP-Fig4)#Mm/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(Eno2-Fig4)#Mm/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(GFAP-Fig4)#Mm/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)721Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)721Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0002654 spongiform encephalopathy "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)721Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(GFAP-Fig4)#Mm/?
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CAST/Ei * SJL

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Nlrp3tm1Bhk/Nlrp3tm1Bhk
Genetic Background: involves: 129S6/SvEvTac

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)721Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004338 small clavicle "reduced size of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0004831 long incisors "increased length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0005075 abnormal melanosome morphology "anomalous structure of these tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)721Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)721Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)705Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

Allelic Composition: Fig4plt1/Fig4plt1,Tg(ACTB-Fig4*I41T)721Mm/0
Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
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Allelic Composition: Fig4plt1/Fig4plt1
Genetic Background: involves: 129P2/OlaHsd * C3H * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010936 Vac14 / Q80WQ2 / Vac14 homolog (S. cerevisiae) / Q08AM6* / Vac14, PIKFYVE complex component*  / complex
 ENSMUSG00000025949 Q9Z1T6 / Pikfyve / phosphoinositide kinase, FYVE type zinc finger containing / Q9Y2I7*  / complex






 

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