ENSMUSG00000011118


Mus musculus

Features
Gene ID: ENSMUSG00000011118
  
Biological name :Panx3
  
Synonyms : Pannexin-3 / Panx3 / Q8CEG0
  
Possible biological names infered from orthology : Q96QZ0
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 37659902
Gene end: 37669235
  
Corresponding Affymetrix probe sets: 10592355 (MoGene1.0st)   1432860_at (Mouse Genome 430 2.0 Array)   1454387_at (Mouse Genome 430 2.0 Array)   1456073_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114539
Ensembl peptide - ENSMUSP00000011262
NCBI entrez gene - 208098     See in Manteia.
MGI - MGI:1918881
RefSeq - NM_172454
RefSeq Peptide - NP_766042
swissprot - D6RDS8
swissprot - Q6IMP0
swissprot - Q8CEG0
Ensembl - ENSMUSG00000011118
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 panx3ENSDARG00000004627Danio rerio
 PANX3ENSGALG00000021443Gallus gallus
 PANX3ENSG00000154143Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Panx1 / Q9JIP4 / Pannexin-1 / Q96RD7*ENSMUSG0000003193438
Panx2 / Q6IMP4 / Pannexin-2 / Q96RD6*ENSMUSG0000005844126


Protein motifs (from Interpro)
Interpro ID Name
 IPR000990  Innexin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IBA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0034214 protein hexamerization ISS
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0022829 wide pore channel activity IBA
 molecular_functionGO:0055077 gap junction hemi-channel activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(TNFSF11)5516Edou/0,Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Orc1tm1a(KOMP)Wtsi/Orc1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Orc1tm1a(KOMP)Wtsi/Wtsi

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Orc1tm1a(KOMP)Wtsi/Orc1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Orc1tm1a(KOMP)Wtsi/Wtsi

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Tg(TNFSF11)5516Edou/0,Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Panx3tm1d(KOMP)Wtsi/Panx3tm1d(KOMP)Wtsi
Genetic Background: involves: BALB/cJ * C3H * C57BL/6 * C57BL/6N

 MP:0010507 shortened RR interval "reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Orc1tm1a(KOMP)Wtsi/Orc1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Orc1tm1a(KOMP)Wtsi/Wtsi

 MP:0013304 osteophytes "bony projections that form along joint margins at bone edges, including the spine; these are frequently found in areas affected by arthritis such as the disc or joint spaces where cartilage has deteriorated" [MGI:mlaw]
Show

Allelic Composition: Tg(TNFSF11)5516Edou/0,Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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