ENSMUSG00000031934


Mus musculus

Features
Gene ID: ENSMUSG00000031934
  
Biological name :Panx1
  
Synonyms : Pannexin-1 / Panx1 / Q9JIP4
  
Possible biological names infered from orthology : Q96RD7
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A2
Gene start: 15002128
Gene end: 15045478
  
Corresponding Affymetrix probe sets: 10590983 (MoGene1.0st)   1416379_at (Mouse Genome 430 2.0 Array)   1440363_at (Mouse Genome 430 2.0 Array)   1441895_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053557
Ensembl peptide - ENSMUSP00000132764
Ensembl peptide - ENSMUSP00000126405
NCBI entrez gene - 55991     See in Manteia.
MGI - MGI:1860055
RefSeq - NM_019482
RefSeq Peptide - NP_062355
swissprot - E9PY07
swissprot - B1PL19
swissprot - Q9JIP4
Ensembl - ENSMUSG00000031934
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 panx1aENSDARG00000025285Danio rerio
 panx1bENSDARG00000014910Danio rerio
 PANX1ENSGALG00000039751Gallus gallus
 PANX1ENSG00000110218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Panx3 / Q8CEG0 / Pannexin-3 / Q96QZ0*ENSMUSG0000001111835
Panx2 / Q6IMP4 / Pannexin-2 / Q96RD6*ENSMUSG0000005844121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000990  Innexin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IGI
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006816 calcium ion transport ISO
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0033198 response to ATP IMP
 biological_processGO:0034214 protein hexamerization IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IMP
 biological_processGO:0050717 positive regulation of interleukin-1 alpha secretion IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0055085 transmembrane transport IGI
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032059 bleb IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0003779 actin binding IPI
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005243 gap junction channel activity IEA
 molecular_functionGO:0005262 calcium channel activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015267 channel activity IGI
 molecular_functionGO:0022829 wide pore channel activity IBA
 molecular_functionGO:0022840 leak channel activity IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051015 actin filament binding IDA
 molecular_functionGO:0055077 gap junction hemi-channel activity IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Electric Transmission Across Gap Junctions
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cers1to/Cers1to
Genetic Background: FVB/N-Cers1to

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1

Allelic Composition: Panx1tm1a(KOMP)Wtsi/Panx1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002983 increased retinal ganglion cell number "greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: C57BL/6 * SJL/J

Allelic Composition: Panx1tm1.1Vshe/Panx1tm1.1Vshe
Genetic Background: B6.129-Panx1tm1.1Vshe

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: C57BL/6 * SJL/J

Allelic Composition: Panx1tm1.1Vshe/Panx1tm1.1Vshe
Genetic Background: B6.129-Panx1tm1.1Vshe

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Panx1tm1.1Fama/Panx1tm1.1Fama,Panx2tm1.1Mony/Panx2tm1.1Mony
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Panx1tm1.1Fama/Panx1+,Panx2tm1.1Mony/Panx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1

Allelic Composition: Panx1tm1a(KOMP)Wtsi/Panx1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: C57BL/6 * SJL/J

Allelic Composition: Panx1tm1.1Vshe/Panx1tm1.1Vshe
Genetic Background: B6.129-Panx1tm1.1Vshe

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clic4tm1.1Aidi/Clic4tm1.1Aidi
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Panx1tm1.1Fama/Panx1tm1.1Fama,Panx2tm1.1Mony/Panx2tm1.1Mony
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nsun2tm1c(EUCOMM)Wtsi/Nsun2tm1c(EUCOMM)Wtsi,Tg(KRT14-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029468 P2rx7 / Q9Z1M0 / P2X purinoceptor 7 / Q99572* / purinergic receptor P2X 7*  / complex
 ENSMUSG00000031934 Panx1 / Q9JIP4 / Pannexin-1 / Q96RD7*  / complex
 ENSMUSG00000058441 Panx2 / Q6IMP4 / Pannexin-2 / Q96RD6*  / complex






 

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