ENSMUSG00000029468


Mus musculus

Features
Gene ID: ENSMUSG00000029468
  
Biological name :P2rx7
  
Synonyms : P2rx7 / P2X purinoceptor 7 / Q9Z1M0
  
Possible biological names infered from orthology : purinergic receptor P2X 7 / Q99572
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 122643911
Gene end: 122691432
  
Corresponding Affymetrix probe sets: 10525419 (MoGene1.0st)   1419853_a_at (Mouse Genome 430 2.0 Array)   1422218_at (Mouse Genome 430 2.0 Array)   1439787_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031425
Ensembl peptide - ENSMUSP00000083425
Ensembl peptide - ENSMUSP00000098303
Ensembl peptide - ENSMUSP00000112440
NCBI entrez gene - 18439     See in Manteia.
MGI - MGI:1339957
RefSeq - NM_001284402
RefSeq - NM_001038839
RefSeq - NM_001038845
RefSeq - NM_001038887
RefSeq - NM_011027
RefSeq Peptide - NP_035157
RefSeq Peptide - NP_001033928
RefSeq Peptide - NP_001033934
RefSeq Peptide - NP_001033976
RefSeq Peptide - NP_001271331
swissprot - F8WI93
swissprot - Q3UN00
swissprot - Q6P5P0
swissprot - Q8CHP4
swissprot - Q9Z1M0
Ensembl - ENSMUSG00000029468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2rx7ENSDARG00000042440Danio rerio
 P2RX7ENSGALG00000003863Gallus gallus
 P2RX7ENSG00000089041Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2rx4 / purinergic receptor P2X 4 / Q99571*ENSMUSG0000002947030
P2rx5 / purinergic receptor P2X, ligand-gated ion channel, 5 / Q93086* / P2RX5-TAX1BP3* / purinergic receptor P2X 5* / P2RX5-TAX1BP3 readthrough (NMD candidate)*ENSMUSG0000000595027
P2rx2 / Q8K3P1 / P2X purinoceptor 2 / Q9UBL9* / purinergic receptor P2X 2*ENSMUSG0000002950327
P2rx1 / P51576 / P2X purinoceptor 1 / P51575* / purinergic receptor P2X 1*ENSMUSG0000002078726
P2rx3 / Q3UR32 / P2X purinoceptor 3 / P56373* / purinergic receptor P2X 3*ENSMUSG0000002707125
P2rx6 / purinergic receptor P2X 6 / O15547*ENSMUSG0000002275823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003050  P2X7 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001845 phagolysosome assembly IMP
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0006509 membrane protein ectodomain proteolysis IMP
 biological_processGO:0006649 phospholipid transfer to membrane IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IMP
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0006884 cell volume homeostasis IDA
 biological_processGO:0006900 vesicle budding from membrane IMP
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007005 mitochondrion organization IDA
 biological_processGO:0007009 plasma membrane organization IDA
 biological_processGO:0009612 response to mechanical stimulus IMP
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0010033 response to organic substance IMP
 biological_processGO:0010043 response to zinc ion IMP
 biological_processGO:0010467 gene expression IMP
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0012501 programmed cell death IMP
 biological_processGO:0014049 positive regulation of glutamate secretion IMP
 biological_processGO:0014054 positive regulation of gamma-aminobutyric acid secretion IMP
 biological_processGO:0014070 response to organic cyclic compound IDA
 biological_processGO:0016079 synaptic vesicle exocytosis IMP
 biological_processGO:0016485 protein processing IMP
 biological_processGO:0017121 phospholipid scrambling IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0019835 cytolysis IMP
 biological_processGO:0030501 positive regulation of bone mineralization IMP
 biological_processGO:0031668 cellular response to extracellular stimulus IMP
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0032308 positive regulation of prostaglandin secretion IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0032963 collagen metabolic process IMP
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0034405 response to fluid shear stress IMP
 biological_processGO:0034767 positive regulation of ion transmembrane transport IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0042098 T cell proliferation IMP
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0043132 NAD transport IMP
 biological_processGO:0043409 negative regulation of MAPK cascade IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0045332 phospholipid translocation IDA
 biological_processGO:0045778 positive regulation of ossification IMP
 biological_processGO:0045779 negative regulation of bone resorption IMP
 biological_processGO:0045794 negative regulation of cell volume IEA
 biological_processGO:0045821 positive regulation of glycolytic process IEA
 biological_processGO:0046513 ceramide biosynthetic process IDA
 biological_processGO:0046931 pore complex assembly IEA
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0050714 positive regulation of protein secretion IDA
 biological_processGO:0050715 positive regulation of cytokine secretion IMP
 biological_processGO:0050717 positive regulation of interleukin-1 alpha secretion IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0051592 response to calcium ion IMP
 biological_processGO:0051602 response to electrical stimulus IMP
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IMP
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0070230 positive regulation of lymphocyte apoptotic process IMP
 biological_processGO:0071359 cellular response to dsRNA IMP
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IMP
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:1904172 positive regulation of bleb assembly ISO
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IEA
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015267 channel activity ISO


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: P2rx7P451L/P2rx7P451L
Genetic Background: C57BL/6

 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Enpp3tm1Ktak/Enpp3tm1Ktak,P2rx7tm1Gab/P2rx7tm1Gab
Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6) or (involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: P2rx7P451L/P2rx7P451L
Genetic Background: C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

Allelic Composition: P2rx7tm1Blo/P2rx7tm1Blo
Genetic Background: involves: 129 * C57BL/6

 MP:0002606 increased basophil count "higher than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: Enpp3tm1Ktak/Enpp3tm1Ktak,P2rx7tm1Gab/P2rx7tm1Gab
Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6) or (involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6)

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008150 decreased diameter of long bones "reduced width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008156 decreased diameter of tibia "reduced width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008704 abnormal interleukin-6 secretion "anomaly in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011958 increased compensatory feeding amount "increased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029468 P2rx7 / Q9Z1M0 / P2X purinoceptor 7 / Q99572* / purinergic receptor P2X 7*  / complex
 ENSMUSG00000031934 Panx1 / Q9JIP4 / Pannexin-1 / Q96RD7*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr