ENSMUSG00000029503


Mus musculus

Features
Gene ID: ENSMUSG00000029503
  
Biological name :P2rx2
  
Synonyms : P2rx2 / P2X purinoceptor 2 / Q8K3P1
  
Possible biological names infered from orthology : purinergic receptor P2X 2 / Q9UBL9
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 110339812
Gene end: 110343212
  
Corresponding Affymetrix probe sets: 10532346 (MoGene1.0st)   1435212_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054233
Ensembl peptide - ENSMUSP00000108097
Ensembl peptide - ENSMUSP00000142567
Ensembl peptide - ENSMUSP00000143047
Ensembl peptide - ENSMUSP00000143554
NCBI entrez gene - 231602     See in Manteia.
MGI - MGI:2665170
RefSeq - XM_011249448
RefSeq - NM_001164833
RefSeq - NM_001164834
RefSeq - NM_001310700
RefSeq - NM_001310701
RefSeq - NM_153400
RefSeq - XM_006534920
RefSeq - XM_006534921
RefSeq - XM_011249447
RefSeq Peptide - NP_700449
RefSeq Peptide - NP_001158305
RefSeq Peptide - NP_001158306
RefSeq Peptide - NP_001297629
RefSeq Peptide - NP_001297630
swissprot - Q8K3P1
Ensembl - ENSMUSG00000029503
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2rx2ENSDARG00000002300Danio rerio
 P2RX2ENSGALG00000044649Gallus gallus
 P2RX2ENSG00000187848Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2rx3 / Q3UR32 / P2X purinoceptor 3 / P56373* / purinergic receptor P2X 3*ENSMUSG0000002707136
P2rx4 / purinergic receptor P2X 4 / Q99571*ENSMUSG0000002947035
P2rx5 / purinergic receptor P2X, ligand-gated ion channel, 5 / Q93086* / P2RX5-TAX1BP3* / purinergic receptor P2X 5* / P2RX5-TAX1BP3 readthrough (NMD candidate)*ENSMUSG0000000595035
P2rx7 / Q9Z1M0 / P2X purinoceptor 7 / Q99572* / purinergic receptor P2X 7*ENSMUSG0000002946832
P2rx6 / purinergic receptor P2X 6 / O15547*ENSMUSG0000002275831
P2rx1 / P51576 / P2X purinoceptor 1 / P51575* / purinergic receptor P2X 1*ENSMUSG0000002078730


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003045  P2X2 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0009743 response to carbohydrate IMP
 biological_processGO:0010033 response to organic substance IMP
 biological_processGO:0014832 urinary bladder smooth muscle contraction IMP
 biological_processGO:0030432 peristalsis IMP
 biological_processGO:0033198 response to ATP IMP
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0048266 behavioral response to pain IMP
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0050909 sensory perception of taste IGI
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IBA
 molecular_functionGO:0003713 transcription coactivator activity ISS
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity ISO
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Grhl3ct/Grhl3ct-J
Genetic Background: Not Specified

 MP:0003438 abnormal carotid body physiology "any functional change in a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grhl3ct/Grhl3ct-J
Genetic Background: Not Specified

Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005576 decreased pulmonary ventilation "less than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Grhl3ct/Grhl3ct-J
Genetic Background: Not Specified

Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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