ENSMUSG00000022758


Mus musculus

Features
Gene ID: ENSMUSG00000022758
  
Biological name :P2rx6
  
Synonyms : P2rx6 / purinergic receptor P2X 6
  
Possible biological names infered from orthology : O15547
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 17561885
Gene end: 17572011
  
Corresponding Affymetrix probe sets: 10434052 (MoGene1.0st)   1450327_at (Mouse Genome 430 2.0 Array)   1456925_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132727
Ensembl peptide - ENSMUSP00000023441
NCBI entrez gene - 18440     See in Manteia.
MGI - MGI:1337113
RefSeq - NM_011028
RefSeq - NM_001159561
RefSeq - XM_006521856
RefSeq Peptide - NP_001153033
RefSeq Peptide - NP_035158
swissprot - G3X8W3
swissprot - E9PY29
Ensembl - ENSMUSG00000022758
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P2RX6ENSGALG00000026902Gallus gallus
 P2RX6ENSG00000099957Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2rx5 / purinergic receptor P2X, ligand-gated ion channel, 5 / Q93086* / P2RX5-TAX1BP3* / purinergic receptor P2X 5* / P2RX5-TAX1BP3 readthrough (NMD candidate)*ENSMUSG0000000595047
P2rx1 / P51576 / P2X purinoceptor 1 / P51575* / purinergic receptor P2X 1*ENSMUSG0000002078744
P2rx4 / purinergic receptor P2X 4 / Q99571*ENSMUSG0000002947044
P2rx2 / Q8K3P1 / P2X purinoceptor 2 / Q9UBL9* / purinergic receptor P2X 2*ENSMUSG0000002950339
P2rx3 / Q3UR32 / P2X purinoceptor 3 / P56373* / purinergic receptor P2X 3*ENSMUSG0000002707138
P2rx7 / Q9Z1M0 / P2X purinoceptor 7 / Q99572* / purinergic receptor P2X 7*ENSMUSG0000002946835


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003049  P2X6 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IEA
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Nr1d2tm1Dgen/Nr1d2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Nr1d2tm1Dgen/Nr1d2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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