ENSG00000099957


Homo sapiens

Features
Gene ID: ENSG00000099957
  
Biological name :P2RX6
  
Synonyms : O15547 / P2RX6 / purinergic receptor P2X 6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q11.21
Gene start: 21009808
Gene end: 21028830
  
Corresponding Affymetrix probe sets: 206880_at (Human Genome U133 Plus 2.0 Array)   211147_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407920
Ensembl peptide - ENSP00000404223
Ensembl peptide - ENSP00000416193
Ensembl peptide - ENSP00000385309
Ensembl peptide - ENSP00000398347
Ensembl peptide - ENSP00000401192
NCBI entrez gene - 9127     See in Manteia.
OMIM - 608077
RefSeq - XM_017029076
RefSeq - XM_017029069
RefSeq - XM_017029070
RefSeq - XM_017029071
RefSeq - XM_017029072
RefSeq - XM_017029073
RefSeq - XM_017029074
RefSeq - XM_017029075
RefSeq - NM_001159554
RefSeq - NM_005446
RefSeq - XM_005261819
RefSeq - XM_011530498
RefSeq - XM_011530499
RefSeq - XM_011530500
RefSeq - XM_011530501
RefSeq - XM_011530502
RefSeq - XM_017029066
RefSeq - XM_017029067
RefSeq - XM_017029068
RefSeq Peptide - NP_001153026
RefSeq Peptide - NP_005437
swissprot - H7C2V4
swissprot - H7C140
swissprot - E7ES48
swissprot - O15547
swissprot - H7C266
Ensembl - ENSG00000099957
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P2RX6ENSGALG00000026902Gallus gallus
 P2rx6ENSMUSG00000022758Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2RX5-TAX1BP3 / P2RX5-TAX1BP3 readthrough (NMD candidate)ENSG0000025795040
P2RX5 / Q93086 / purinergic receptor P2X 5ENSG0000008345440
P2RX4 / Q99571 / purinergic receptor P2X 4ENSG0000013512438
P2RX1 / P51575 / purinergic receptor P2X 1ENSG0000010840537
P2RX2 / Q9UBL9 / purinergic receptor P2X 2ENSG0000018784835
P2RX3 / P56373 / purinergic receptor P2X 3ENSG0000010999133
P2RX7 / Q99572 / purinergic receptor P2X 7ENSG0000008904132


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003049  P2X6 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0051260 protein homooligomerization IPI
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015267 channel activity TAS
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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