ENSG00000135124


Homo sapiens

Features
Gene ID: ENSG00000135124
  
Biological name :P2RX4
  
Synonyms : P2RX4 / purinergic receptor P2X 4 / Q99571
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.31
Gene start: 121209857
Gene end: 121234106
  
Corresponding Affymetrix probe sets: 204088_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444274
Ensembl peptide - ENSP00000439386
Ensembl peptide - ENSP00000444033
Ensembl peptide - ENSP00000336607
Ensembl peptide - ENSP00000353032
Ensembl peptide - ENSP00000437396
Ensembl peptide - ENSP00000438131
Ensembl peptide - ENSP00000438329
NCBI entrez gene - 5025     See in Manteia.
OMIM - 600846
RefSeq - XM_011538416
RefSeq - NM_001256796
RefSeq - NM_001261397
RefSeq - NM_001261398
RefSeq - NM_002560
RefSeq Peptide - NP_001248327
RefSeq Peptide - NP_002551
RefSeq Peptide - NP_001243725
RefSeq Peptide - NP_001248326
swissprot - F6SFZ6
swissprot - H0YF70
swissprot - F5H1M6
swissprot - F5H2S3
swissprot - Q99571
swissprot - F5GZQ9
Ensembl - ENSG00000135124
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2rx4aENSDARG00000044752Danio rerio
 p2rx4bENSDARG00000042452Danio rerio
 P2RX4ENSGALG00000003901Gallus gallus
 P2rx4ENSMUSG00000029470Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2RX1 / P51575 / purinergic receptor P2X 1ENSG0000010840549
P2RX5 / Q93086 / purinergic receptor P2X 5ENSG0000008345448
P2RX5-TAX1BP3 / P2RX5-TAX1BP3 readthrough (NMD candidate)ENSG0000025795048
P2RX2 / Q9UBL9 / purinergic receptor P2X 2ENSG0000018784845
P2RX7 / Q99572 / purinergic receptor P2X 7ENSG0000008904144
P2RX6 / O15547 / purinergic receptor P2X 6ENSG0000009995742
P2RX3 / P56373 / purinergic receptor P2X 3ENSG0000010999142


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003047  P2X4 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001894 tissue homeostasis NAS
 biological_processGO:0002028 regulation of sodium ion transport ISS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IMP
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IMP
 biological_processGO:0019228 neuronal action potential IEA
 biological_processGO:0019233 sensory perception of pain ISS
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0032308 positive regulation of prostaglandin secretion NAS
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0034220 ion transmembrane transport IDA
 biological_processGO:0034405 response to fluid shear stress IDA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0042118 endothelial cell activation TAS
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IMP
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process NAS
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051899 membrane depolarization IDA
 biological_processGO:0051928 positive regulation of calcium ion transport NAS
 biological_processGO:0055117 regulation of cardiac muscle contraction IMP
 biological_processGO:0055119 relaxation of cardiac muscle IMP
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0070588 calcium ion transmembrane transport IDA
 biological_processGO:0071318 cellular response to ATP IDA
 biological_processGO:0097190 apoptotic signaling pathway IDA
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis IMP
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IEA
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IEA
 molecular_functionGO:0005102 signaling receptor binding ISS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005507 copper ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity NAS
 molecular_functionGO:0045296 cadherin binding IPI
 molecular_functionGO:0099604 ligand-gated calcium channel activity IDA


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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