ENSG00000109991


Homo sapiens

Features
Gene ID: ENSG00000109991
  
Biological name :P2RX3
  
Synonyms : P2RX3 / P56373 / purinergic receptor P2X 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q12.1
Gene start: 57338374
Gene end: 57370600
  
Corresponding Affymetrix probe sets: 208338_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484614
Ensembl peptide - ENSP00000263314
Ensembl peptide - ENSP00000434166
NCBI entrez gene - 5024     See in Manteia.
OMIM - 600843
RefSeq - XM_011545073
RefSeq - XM_011545069
RefSeq - XM_011545070
RefSeq - XM_011545071
RefSeq - XM_011545072
RefSeq - NM_002559
RefSeq Peptide - NP_002550
swissprot - H0YDR6
swissprot - A0A087X210
swissprot - P56373
Ensembl - ENSG00000109991
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2rx3aENSDARG00000010477Danio rerio
 p2rx3bENSDARG00000029718Danio rerio
 P2RX3ENSGALG00000040479Gallus gallus
 P2rx3ENSMUSG00000027071Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2RX2 / Q9UBL9 / purinergic receptor P2X 2ENSG0000018784847
P2RX1 / P51575 / purinergic receptor P2X 1ENSG0000010840543
P2RX4 / Q99571 / purinergic receptor P2X 4ENSG0000013512443
P2RX5 / Q93086 / purinergic receptor P2X 5ENSG0000008345440
P2RX5-TAX1BP3 / P2RX5-TAX1BP3 readthrough (NMD candidate)ENSG0000025795040
P2RX7 / Q99572 / purinergic receptor P2X 7ENSG0000008904138
P2RX6 / O15547 / purinergic receptor P2X 6ENSG0000009995737


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003046  P2X3 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007274 neuromuscular synaptic transmission IEA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0009266 response to temperature stimulus IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009743 response to carbohydrate IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol NAS
 biological_processGO:0014832 urinary bladder smooth muscle contraction IEA
 biological_processGO:0019228 neuronal action potential IEA
 biological_processGO:0030432 peristalsis IEA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048266 behavioral response to pain IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling NAS
 biological_processGO:0050909 sensory perception of taste IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0061368 behavioral response to formalin induced pain IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:1904058 positive regulation of sensory perception of pain IEA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IEA
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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