ENSMUSG00000020787


Mus musculus

Features
Gene ID: ENSMUSG00000020787
  
Biological name :P2rx1
  
Synonyms : P2rx1 / P2X purinoceptor 1 / P51576
  
Possible biological names infered from orthology : P51575 / purinergic receptor P2X 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B4
Gene start: 72999103
Gene end: 73015200
  
Corresponding Affymetrix probe sets: 10378240 (MoGene1.0st)   1429794_a_at (Mouse Genome 430 2.0 Array)   1460719_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090614
Ensembl peptide - ENSMUSP00000021141
NCBI entrez gene - 18436     See in Manteia.
MGI - MGI:1098235
RefSeq - NM_008771
RefSeq - XM_006532451
RefSeq Peptide - NP_032797
swissprot - B1AUD1
swissprot - P51576
Ensembl - ENSMUSG00000020787
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p2rx1ENSDARG00000016695Danio rerio
 P2RX1ENSGALG00000001573Gallus gallus
 P2RX1ENSG00000108405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P2rx4 / purinergic receptor P2X 4 / Q99571*ENSMUSG0000002947049
P2rx6 / purinergic receptor P2X 6 / O15547*ENSMUSG0000002275843
P2rx3 / Q3UR32 / P2X purinoceptor 3 / P56373* / purinergic receptor P2X 3*ENSMUSG0000002707141
P2rx5 / purinergic receptor P2X, ligand-gated ion channel, 5 / Q93086* / P2RX5-TAX1BP3* / purinergic receptor P2X 5* / P2RX5-TAX1BP3 readthrough (NMD candidate)*ENSMUSG0000000595041
P2rx7 / Q9Z1M0 / P2X purinoceptor 7 / Q99572* / purinergic receptor P2X 7*ENSMUSG0000002946839
P2rx2 / Q8K3P1 / P2X purinoceptor 2 / Q9UBL9* / purinergic receptor P2X 2*ENSMUSG0000002950338


Protein motifs (from Interpro)
Interpro ID Name
 IPR001429  P2X purinoreceptor
 IPR003044  P2X1 purinoceptor
 IPR027309  P2X purinoreceptor extracellular domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002554 serotonin secretion by platelet IMP
 biological_processGO:0003056 regulation of vascular smooth muscle contraction IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0006940 regulation of smooth muscle contraction IMP
 biological_processGO:0007320 insemination IMP
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0010033 response to organic substance IMP
 biological_processGO:0019228 neuronal action potential IEA
 biological_processGO:0019229 regulation of vasoconstriction IMP
 biological_processGO:0030168 platelet activation IMP
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0043270 positive regulation of ion transport IMP
 biological_processGO:0046513 ceramide biosynthetic process IDA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051924 regulation of calcium ion transport IMP
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0001614 purinergic nucleotide receptor activity IEA
 molecular_functionGO:0004931 extracellularly ATP-gated cation channel activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
Elevation of cytosolic Ca2+ levels
Platelet homeostasis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002769 abnormal vas deferens morphology "malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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