ENSG00000110218


Homo sapiens

Features
Gene ID: ENSG00000110218
  
Biological name :PANX1
  
Synonyms : pannexin 1 / PANX1 / Q96RD7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q21
Gene start: 94128928
Gene end: 94181972
  
Corresponding Affymetrix probe sets: 204715_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000227638
Ensembl peptide - ENSP00000411461
NCBI entrez gene - 24145     See in Manteia.
OMIM - 608420
RefSeq - NM_015368
RefSeq - XM_017017464
RefSeq Peptide - NP_056183
swissprot - A0A024R397
swissprot - Q96RD7
Ensembl - ENSG00000110218
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 panx1aENSDARG00000025285Danio rerio
 panx1bENSDARG00000014910Danio rerio
 PANX1ENSGALG00000039751Gallus gallus
 Panx1ENSMUSG00000031934Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PANX3 / Q96QZ0 / pannexin 3ENSG0000015414337
PANX2 / Q96RD6 / pannexin 2ENSG0000007315021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000990  Innexin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IDA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0034214 protein hexamerization IDA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050717 positive regulation of interleukin-1 alpha secretion IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032059 bleb IDA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005243 gap junction channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IMP
 molecular_functionGO:0015267 channel activity IEA
 molecular_functionGO:0022840 leak channel activity IMP
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0055077 gap junction hemi-channel activity IDA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Electric Transmission Across Gap Junctions
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000073150 PANX2 / Q96RD6 / pannexin 2  / complex
 ENSG00000110218 PANX1 / Q96RD7 / pannexin 1  / complex
 ENSG00000089041 P2RX7 / Q99572 / purinergic receptor P2X 7  / complex






 

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