ENSMUSG00000012609


Mus musculus

Features
Gene ID: ENSMUSG00000012609
  
Biological name :Ttll5
  
Synonyms : Q8CHB8 / Ttll5 / tubulin tyrosine ligase-like family, member 5
  
Possible biological names infered from orthology : Q6EMB2 / tubulin tyrosine ligase like 5
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D2
Gene start: 85824659
Gene end: 86061893
  
Corresponding Affymetrix probe sets: 10397377 (MoGene1.0st)   1430469_at (Mouse Genome 430 2.0 Array)   1431279_s_at (Mouse Genome 430 2.0 Array)   1452890_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135712
Ensembl peptide - ENSMUSP00000135395
Ensembl peptide - ENSMUSP00000135730
Ensembl peptide - ENSMUSP00000135852
Ensembl peptide - ENSMUSP00000039939
Ensembl peptide - ENSMUSP00000048809
Ensembl peptide - ENSMUSP00000093192
Ensembl peptide - ENSMUSP00000105849
Ensembl peptide - ENSMUSP00000105853
Ensembl peptide - ENSMUSP00000122530
Ensembl peptide - ENSMUSP00000134874
Ensembl peptide - ENSMUSP00000134928
Ensembl peptide - ENSMUSP00000134934
Ensembl peptide - ENSMUSP00000134971
Ensembl peptide - ENSMUSP00000135139
Ensembl peptide - ENSMUSP00000135279
NCBI entrez gene - 320244     See in Manteia.
MGI - MGI:2443657
RefSeq - XM_017315115
RefSeq - XM_006515998
RefSeq - XM_006515999
RefSeq - XM_006516001
RefSeq - XM_006516003
RefSeq - XM_006516004
RefSeq - XM_006516005
RefSeq - XM_006516006
RefSeq - XM_006516007
RefSeq - XM_006516008
RefSeq - XM_017315108
RefSeq - XM_017315109
RefSeq - XM_017315110
RefSeq - XM_017315111
RefSeq - XM_017315112
RefSeq - XM_017315113
RefSeq - XM_017315114
RefSeq - NM_001081423
RefSeq - XM_006515989
RefSeq - XM_006515990
RefSeq - XM_006515991
RefSeq - XM_006515992
RefSeq - XM_006515993
RefSeq - XM_006515994
RefSeq - XM_006515995
RefSeq - XM_006515996
RefSeq - XM_006515997
RefSeq Peptide - NP_001334324
RefSeq Peptide - NP_001074892
swissprot - H3BJC2
swissprot - H3BJC7
swissprot - H3BJV4
swissprot - H3BK74
swissprot - H3BLA3
swissprot - H3BLC0
swissprot - H3BLN3
swissprot - D3Z5H9
swissprot - D3YVZ5
swissprot - Q8BUF0
swissprot - Q8C125
swissprot - E9Q425
swissprot - Q8CHB8
swissprot - H3BJ73
Ensembl - ENSMUSG00000012609
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttll5ENSDARG00000036793Danio rerio
 TTLL5ENSGALG00000010340Gallus gallus
 TTLL5ENSG00000119685Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ttll4 / Q80UG8 / tubulin tyrosine ligase-like family, member 4 / Q14679* / tubulin tyrosine ligase like 4*ENSMUSG0000003325716
Ttll6 / A4Q9E8 / tubulin tyrosine ligase-like family, member 6 / Q8N841* / tubulin tyrosine ligase like 6*ENSMUSG0000003875615
Ttll13 / A4Q9F6 / tubulin tyrosine ligase-like family, member 13 / A6NNM8* / TTLL13P* / tubulin tyrosine ligase like 13, pseudogene*ENSMUSG0000004546714
Ttll7 / tubulin tyrosine ligase-like family, member 7 / Q6ZT98* / tubulin tyrosine ligase like 7*ENSMUSG0000003674513
Ttll2 / A4Q9E4 / tubulin tyrosine ligase-like family, member 2 / Q9BWV7* / tubulin tyrosine ligase like 2*ENSMUSG0000007972211
A4Q9F4 / Ttll11 / tubulin tyrosine ligase-like family, member 11 / Q8NHH1* / tubulin tyrosine ligase like 11*ENSMUSG0000002688510
Ttll9 / A2APC3 / tubulin tyrosine ligase-like family, member 9 / Q3SXZ7* / tubulin tyrosine ligase like 9*ENSMUSG000000746739
Ttll1 / Q91V51 / tubulin tyrosine ligase-like 1 / O95922*ENSMUSG000000224429
Ttll3 / A4Q9E5 / tubulin tyrosine ligase-like family, member 3 / Q9Y4R7* / ARPC4-TTLL3* / ARPC4-TTLL3 readthrough* / tubulin tyrosine ligase like 3*ENSMUSG000000302769
Ttll8 / A4Q9F1 / tubulin tyrosine ligase-like family, member 8 / A6PVC2* / tubulin tyrosine ligase like 8*ENSMUSG000000223888
Ttll10 / tubulin tyrosine ligase-like family, member 10 / Q6ZVT0* / tubulin tyrosine ligase like 10*ENSMUSG000000290748


Protein motifs (from Interpro)
Interpro ID Name
 IPR004344  Tubulin-tyrosine ligase/Tubulin polyglutamylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007288 sperm axoneme assembly IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0018095 protein polyglutamylation IMP
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0060041 retina development in camera-type eye ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Carboxyterminal post-translational modifications of tubulin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

Allelic Composition: Ttll5tm1.1N/Ttll5tm1.1N
Genetic Background: B6.Cg-Ttll5tm1.1N

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

Allelic Composition: Ttll5tm1.1N/Ttll5tm1.1N
Genetic Background: B6.Cg-Ttll5tm1.1N

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

 MP:0009647 decreased fertilization frequency "he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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