ENSMUSG00000030276


Mus musculus

Features
Gene ID: ENSMUSG00000030276
  
Biological name :Ttll3
  
Synonyms : A4Q9E5 / Ttll3 / tubulin tyrosine ligase-like family, member 3
  
Possible biological names infered from orthology : ARPC4-TTLL3 / ARPC4-TTLL3 readthrough / Q9Y4R7 / tubulin tyrosine ligase like 3
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 113389260
Gene end: 113414587
  
Corresponding Affymetrix probe sets: 10540659 (MoGene1.0st)   1421219_at (Mouse Genome 430 2.0 Array)   1436604_at (Mouse Genome 430 2.0 Array)   1451694_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145329
Ensembl peptide - ENSMUSP00000032414
Ensembl peptide - ENSMUSP00000037870
Ensembl peptide - ENSMUSP00000145044
Ensembl peptide - ENSMUSP00000145049
NCBI entrez gene - 101100     See in Manteia.
MGI - MGI:2141418
RefSeq - NM_133923
RefSeq - NM_001142732
RefSeq Peptide - NP_598684
RefSeq Peptide - NP_001136204
swissprot - F8VQA1
swissprot - F6T422
swissprot - A4Q9E5
swissprot - H7BX03
Ensembl - ENSMUSG00000030276
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttll3ENSDARG00000053728Danio rerio
 ENSGALG00000044133Gallus gallus
 ARPC4-TTLL3ENSG00000250151Homo sapiens
 TTLL3ENSG00000214021Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ttll8 / A4Q9F1 / tubulin tyrosine ligase-like family, member 8 / A6PVC2* / tubulin tyrosine ligase like 8*ENSMUSG0000002238833
Ttll5 / Q8CHB8 / tubulin tyrosine ligase-like family, member 5 / Q6EMB2* / tubulin tyrosine ligase like 5*ENSMUSG0000001260913
Ttll6 / A4Q9E8 / tubulin tyrosine ligase-like family, member 6 / Q8N841* / tubulin tyrosine ligase like 6*ENSMUSG0000003875613
Ttll7 / tubulin tyrosine ligase-like family, member 7 / Q6ZT98* / tubulin tyrosine ligase like 7*ENSMUSG0000003674513
Ttll9 / A2APC3 / tubulin tyrosine ligase-like family, member 9 / Q3SXZ7* / tubulin tyrosine ligase like 9*ENSMUSG0000007467312
Ttll4 / Q80UG8 / tubulin tyrosine ligase-like family, member 4 / Q14679* / tubulin tyrosine ligase like 4*ENSMUSG0000003325712
Ttll13 / A4Q9F6 / tubulin tyrosine ligase-like family, member 13 / A6NNM8* / TTLL13P* / tubulin tyrosine ligase like 13, pseudogene*ENSMUSG0000004546712
Ttll10 / tubulin tyrosine ligase-like family, member 10 / Q6ZVT0* / tubulin tyrosine ligase like 10*ENSMUSG0000002907410
A4Q9F4 / Ttll11 / tubulin tyrosine ligase-like family, member 11 / Q8NHH1* / tubulin tyrosine ligase like 11*ENSMUSG0000002688510
Ttll1 / Q91V51 / tubulin tyrosine ligase-like 1 / O95922*ENSMUSG000000224429
Ttll2 / A4Q9E4 / tubulin tyrosine ligase-like family, member 2 / Q9BWV7* / tubulin tyrosine ligase like 2*ENSMUSG000000797229


Protein motifs (from Interpro)
Interpro ID Name
 IPR004344  Tubulin-tyrosine ligase/Tubulin polyglutamylase
 IPR013815  ATP-grasp fold, subdomain 1
 IPR027753  Tubulin monoglycylase TTLL3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0018094 protein polyglycylation IDA
 biological_processGO:0035082 axoneme assembly ISS
 biological_processGO:0060271 cilium assembly IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0070735 protein-glycine ligase activity IDA
 molecular_functionGO:0070736 protein-glycine ligase activity, initiating IDA


Pathways (from Reactome)
Pathway description
Carboxyterminal post-translational modifications of tubulin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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