ENSMUSG00000022442


Mus musculus

Features
Gene ID: ENSMUSG00000022442
  
Biological name :Ttll1
  
Synonyms : Q91V51 / Ttll1 / tubulin tyrosine ligase-like 1
  
Possible biological names infered from orthology : O95922
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 83483769
Gene end: 83510893
  
Corresponding Affymetrix probe sets: 10431017 (MoGene1.0st)   1426427_at (Mouse Genome 430 2.0 Array)   1436833_x_at (Mouse Genome 430 2.0 Array)   1443193_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016897
Ensembl peptide - ENSMUSP00000105105
Ensembl peptide - ENSMUSP00000105106
Ensembl peptide - ENSMUSP00000117790
NCBI entrez gene - 319953     See in Manteia.
MGI - MGI:2443047
RefSeq - XM_011245659
RefSeq - NM_001357953
RefSeq - NM_178869
RefSeq - XM_006521078
RefSeq - XM_006521079
RefSeq Peptide - NP_001344882
RefSeq Peptide - NP_849200
swissprot - Q8BJG7
swissprot - Q91V51
swissprot - A6PW19
Ensembl - ENSMUSG00000022442
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttll1ENSDARG00000090778Danio rerio
 TTLL1ENSGALG00000014163Gallus gallus
 TTLL1ENSG00000100271Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ttll9 / A2APC3 / tubulin tyrosine ligase-like family, member 9 / Q3SXZ7* / tubulin tyrosine ligase like 9*ENSMUSG0000007467340
Ttll5 / Q8CHB8 / tubulin tyrosine ligase-like family, member 5 / Q6EMB2* / tubulin tyrosine ligase like 5*ENSMUSG0000001260928
Ttll13 / A4Q9F6 / tubulin tyrosine ligase-like family, member 13 / A6NNM8* / TTLL13P* / tubulin tyrosine ligase like 13, pseudogene*ENSMUSG0000004546728
Ttll6 / A4Q9E8 / tubulin tyrosine ligase-like family, member 6 / Q8N841* / tubulin tyrosine ligase like 6*ENSMUSG0000003875627
Ttll2 / A4Q9E4 / tubulin tyrosine ligase-like family, member 2 / Q9BWV7* / tubulin tyrosine ligase like 2*ENSMUSG0000007972227
Ttll4 / Q80UG8 / tubulin tyrosine ligase-like family, member 4 / Q14679* / tubulin tyrosine ligase like 4*ENSMUSG0000003325726
Ttll7 / tubulin tyrosine ligase-like family, member 7 / Q6ZT98* / tubulin tyrosine ligase like 7*ENSMUSG0000003674524
A4Q9F4 / Ttll11 / tubulin tyrosine ligase-like family, member 11 / Q8NHH1* / tubulin tyrosine ligase like 11*ENSMUSG0000002688523
Ttll3 / A4Q9E5 / tubulin tyrosine ligase-like family, member 3 / Q9Y4R7* / ARPC4-TTLL3* / ARPC4-TTLL3 readthrough* / tubulin tyrosine ligase like 3*ENSMUSG0000003027621
Ttll10 / tubulin tyrosine ligase-like family, member 10 / Q6ZVT0* / tubulin tyrosine ligase like 10*ENSMUSG0000002907420
Ttll8 / A4Q9F1 / tubulin tyrosine ligase-like family, member 8 / A6PVC2* / tubulin tyrosine ligase like 8*ENSMUSG0000002238819


Protein motifs (from Interpro)
Interpro ID Name
 IPR004344  Tubulin-tyrosine ligase/Tubulin polyglutamylase
 IPR027750  Tubulin polyglutamylase TTLL1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0007288 sperm axoneme assembly IMP
 biological_processGO:0018095 protein polyglutamylation IEA
 biological_processGO:0035082 axoneme assembly IMP
 biological_processGO:1905419 sperm flagellum movement involved in flagellated sperm motility IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0070740 tubulin-glutamic acid ligase activity EXP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001867 rhinitis "inflammation of the mucous membrane of the nose" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001872 sinus inflammation "increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens" [MGI:tc, J:60896]
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Allelic Composition: Slc2a10G128E/Slc2a10G128E
Genetic Background: C3HeB/FeJ-Slc2a10G128E

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001947 abnormal mucociliary clearance "anomaly in the rate of ciliary and secretory activity of the respiratory submucosal glands" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc2a10G128E/Slc2a10G128E
Genetic Background: C3HeB/FeJ-Slc2a10G128E

 MP:0001950 abnormal respiratory sounds "anomalous noises heard over any part of the respiratory tract" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc2a10G128E/Slc2a10G128E
Genetic Background: C3HeB/FeJ-Slc2a10G128E

 MP:0002285 abnormal tracheal ciliated epithelium morphology "structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Slc2a10G128E/Slc2a10G128E
Genetic Background: C3HeB/FeJ-Slc2a10G128E

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008545 absent sperm flagella "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009234 absent sperm head "absence of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009239 short sperm flagellum "decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc2a10G128E/Slc2a10G128E
Genetic Background: C3HeB/FeJ-Slc2a10G128E

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc2a10G128E/Slc2a10G128E
Genetic Background: C3HeB/FeJ-Slc2a10G128E

 MP:0011055 abnormal respiratory motile cilium physiology "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc2a10G128E/Slc2a10G128E
Genetic Background: C3HeB/FeJ-Slc2a10G128E

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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