ENSMUSG00000014592


Mus musculus

Features
Gene ID: ENSMUSG00000014592
  
Biological name :Camta1
  
Synonyms : A2A891 / Calmodulin-binding transcription activator 1 / Camta1
  
Possible biological names infered from orthology : Q9Y6Y1
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 150917322
Gene end: 151861876
  
Corresponding Affymetrix probe sets: 10518812 (MoGene1.0st)   10518833 (MoGene1.0st)   10518835 (MoGene1.0st)   10518837 (MoGene1.0st)   1433971_at (Mouse Genome 430 2.0 Array)   1433972_at (Mouse Genome 430 2.0 Array)   1453455_at (Mouse Genome 430 2.0 Array)   1457956_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127916
Ensembl peptide - ENSMUSP00000149268
Ensembl peptide - ENSMUSP00000134684
Ensembl peptide - ENSMUSP00000054804
Ensembl peptide - ENSMUSP00000095381
Ensembl peptide - ENSMUSP00000101293
Ensembl peptide - ENSMUSP00000101295
Ensembl peptide - ENSMUSP00000118969
Ensembl peptide - ENSMUSP00000119067
NCBI entrez gene - 100072     See in Manteia.
MGI - MGI:2140230
RefSeq - XM_017319881
RefSeq - NM_001081557
RefSeq - NM_001195565
RefSeq Peptide - NP_001182494
RefSeq Peptide - NP_001075026
swissprot - Z4YMK8
swissprot - A2A891
swissprot - Q3TYE0
swissprot - B0QZL6
Ensembl - ENSMUSG00000014592
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camta1aENSDARG00000077428Danio rerio
 camta1bENSDARG00000007824Danio rerio
 CAMTA1ENSGALG00000039525Gallus gallus
 CAMTA1ENSG00000171735Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Camta2 / Q80Y50 / Calmodulin-binding transcription activator 2 / O94983*ENSMUSG0000004071239


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR002110  Ankyrin repeat
 IPR002909  IPT domain
 IPR005559  CG-1 DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR020683  Ankyrin repeat-containing domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nsmftm1a(KOMP)Wtsi/Nsmf+
Genetic Background: involves: C57BL/6N

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Nsmftm1a(KOMP)Wtsi/Nsmf+
Genetic Background: involves: C57BL/6N

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Nsmftm1a(KOMP)Wtsi/Nsmf+
Genetic Background: involves: C57BL/6N

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0006099 thin granule layer "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nsmftm1a(KOMP)Wtsi/Nsmf+
Genetic Background: involves: C57BL/6N

 MP:0014185 cerebellum atrophy "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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