ENSMUSG00000014668


Mus musculus

Features
Gene ID: ENSMUSG00000014668
  
Biological name :Chfr
  
Synonyms : Chfr / E3 ubiquitin-protein ligase CHFR / Q810L3
  
Possible biological names infered from orthology : checkpoint with forkhead and ring finger domains / Q96EP1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 110135842
Gene end: 110171972
  
Corresponding Affymetrix probe sets: 10524105 (MoGene1.0st)   1433550_at (Mouse Genome 430 2.0 Array)   1434529_x_at (Mouse Genome 430 2.0 Array)   1442922_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142482
Ensembl peptide - ENSMUSP00000143113
Ensembl peptide - ENSMUSP00000143737
Ensembl peptide - ENSMUSP00000143480
Ensembl peptide - ENSMUSP00000143389
Ensembl peptide - ENSMUSP00000143310
Ensembl peptide - ENSMUSP00000014812
Ensembl peptide - ENSMUSP00000108138
Ensembl peptide - ENSMUSP00000142354
NCBI entrez gene - 231600     See in Manteia.
MGI - MGI:2444898
RefSeq - XM_011249446
RefSeq - NM_001289577
RefSeq - NM_001289578
RefSeq - NM_001289579
RefSeq - NM_001289580
RefSeq - NM_172717
RefSeq - XM_006534915
RefSeq - XM_011249445
RefSeq Peptide - NP_001276506
RefSeq Peptide - NP_001276507
RefSeq Peptide - NP_001276508
RefSeq Peptide - NP_001276509
RefSeq Peptide - NP_766305
swissprot - A0A0G2JDG0
swissprot - A0A0G2JFU4
swissprot - A0A0G2JGX6
swissprot - A0A0G2JG18
swissprot - Q810L3
swissprot - A0A0G2JFC1
Ensembl - ENSMUSG00000014668
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chfrENSDARG00000075347Danio rerio
 CHFRENSGALG00000002180Gallus gallus
 CHFRENSG00000072609Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001841  Zinc finger, RING-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISO
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019941 modification-dependent protein catabolic process ISO
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0031648 protein destabilization IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0016605 PML body ISS
 molecular_functionGO:0000166 nucleotide binding ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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