ENSMUSG00000015090


Mus musculus

Features
Gene ID: ENSMUSG00000015090
  
Biological name :Ptgds
  
Synonyms : O09114 / Prostaglandin-H2 D-isomerase / Ptgds
  
Possible biological names infered from orthology : AL807752.7 / P41222 / prostaglandin D2 synthase
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 25466709
Gene end: 25470046
  
Corresponding Affymetrix probe sets: 10480734 (MoGene1.0st)   1423859_a_at (Mouse Genome 430 2.0 Array)   1423860_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015234
Ensembl peptide - ENSMUSP00000109889
Ensembl peptide - ENSMUSP00000109897
NCBI entrez gene - 19215     See in Manteia.
MGI - MGI:99261
RefSeq - XM_006497787
RefSeq - NM_008963
RefSeq - XM_006497786
RefSeq Peptide - NP_032989
swissprot - O09114
Ensembl - ENSMUSG00000015090
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lcn15ENSDARG00000067851Danio rerio
 ptgdsaENSDARG00000069439Danio rerio
 ptgdsb.1ENSDARG00000027088Danio rerio
 ptgdsb.2ENSDARG00000071626Danio rerio
 zgc:153704ENSDARG00000045979Danio rerio
 PTGDSENSGALG00000030886Gallus gallus
 AL807752.7ENSG00000284341Homo sapiens
 PTGDSENSG00000107317Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR002345  Lipocalin
 IPR002972  Prostaglandin D synthase
 IPR012674  Calycin
 IPR022272  Lipocalin family conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process ISO
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0045187 regulation of circadian sleep/wake cycle, sleep IDA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:2000255 negative regulation of male germ cell proliferation IGI
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004667 prostaglandin-D synthase activity ISO
 molecular_functionGO:0005501 retinoid binding ISS
 molecular_functionGO:0005504 fatty acid binding ISO
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0036094 small molecule binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000362 reduced histamine storage "decreased amounts of this potent vasoactive peptide stored in mast cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Mir146tm2.1Bal/Mir146tm2.1Bal
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0008020 abnormal dermal mast cell morphology "any structural anomaly in cells located in connective tissue of the dermis that contain numerous basophilic granules and release substances such as heparin and histamine in response to injury or inflammation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0010281 increased nervous system tumor incidence "greater than the expected number of tumors originating in the nervous system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010311 increased meningioma incidence "greater than the expected number of encapsulated neoplasms derived from the meninges, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010313 increased osteoma incidence "greater than the expected number of benign neoplasms derived from lamellar bone, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Ptgdstm1.1(cre)Gvn/Ptgds+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr