ENSMUSG00000015452


Mus musculus

Features
Gene ID: ENSMUSG00000015452
  
Biological name :Ager
  
Synonyms : Advanced glycosylation end product-specific receptor / Ager / Q62151
  
Possible biological names infered from orthology : Q15109
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34597862
Gene end: 34600936
  
Corresponding Affymetrix probe sets: 10444407 (MoGene1.0st)   1420428_at (Mouse Genome 430 2.0 Array)   1441958_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015596
Ensembl peptide - ENSMUSP00000133391
Ensembl peptide - ENSMUSP00000134401
Ensembl peptide - ENSMUSP00000134579
NCBI entrez gene - 11596     See in Manteia.
MGI - MGI:893592
RefSeq - XM_006523501
RefSeq - NM_001271422
RefSeq - NM_001271423
RefSeq - NM_001271424
RefSeq - NM_007425
RefSeq Peptide - NP_001258352
RefSeq Peptide - NP_001258353
RefSeq Peptide - NP_031451
RefSeq Peptide - NP_001258351
swissprot - Q62151
Ensembl - ENSMUSG00000015452
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AGERENSG00000204305Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0001914 regulation of T cell mediated cytotoxicity ISO
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007611 learning or memory ISO
 biological_processGO:0010255 glucose mediated signaling pathway ISO
 biological_processGO:0014002 astrocyte development IMP
 biological_processGO:0023056 positive regulation of signaling ISO
 biological_processGO:0023057 negative regulation of signaling ISO
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0030336 negative regulation of cell migration ISO
 biological_processGO:0031175 neuron projection development ISO
 biological_processGO:0032693 negative regulation of interleukin-10 production ISO
 biological_processGO:0032735 positive regulation of interleukin-12 production ISO
 biological_processGO:0042104 positive regulation of activated T cell proliferation ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0046330 positive regulation of JNK cascade ISO
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0050930 induction of positive chemotaxis IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051101 regulation of DNA binding IMP
 biological_processGO:0061890 positive regulation of astrocyte activation ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IGI
 biological_processGO:0072657 protein localization to membrane IMP
 biological_processGO:0090647 modulation of age-related behavioral decline ISO
 biological_processGO:0150003 regulation of spontaneous synaptic transmission ISO
 biological_processGO:1900271 regulation of long-term synaptic potentiation IMP
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation ISO
 biological_processGO:1900453 negative regulation of long term synaptic depression ISO
 biological_processGO:1900744 regulation of p38MAPK cascade IGI
 biological_processGO:1900745 positive regulation of p38MAPK cascade ISO
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling ISO
 biological_processGO:1903980 positive regulation of microglial cell activation ISO
 biological_processGO:1904597 negative regulation of connective tissue replacement involved in inflammatory response wound healing IMP
 biological_processGO:1904604 negative regulation of advanced glycation end-product receptor activity ISO
 biological_processGO:1904605 positive regulation of advanced glycation end-product receptor activity ISO
 biological_processGO:1904645 response to amyloid-beta IGI
 biological_processGO:1904646 cellular response to amyloid-beta IMP
 biological_processGO:2000514 regulation of CD4-positive, alpha-beta T cell activation ISO
 biological_processGO:2001200 positive regulation of dendritic cell differentiation ISO
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0030054 cell junction ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0038023 signaling receptor activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044548 S100 protein binding IPI
 molecular_functionGO:1904599 advanced glycation end-product binding IDA


Pathways (from Reactome)
Pathway description
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1(Nfkbia)Rsu/Ctnnb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm1(Nfkbia)Rsu/Ctnnb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ctnnb1tm1(Nfkbia)Rsu/Ctnnb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp8tm1.1Yuan/Casp8tm1.1Yuan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * MF1

Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam,Tg(Ins2-Nos2)40Okam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002706 abnormal kidney size "anomalous physical bulk one or both of the organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam,Tg(Ins2-Nos2)40Okam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2

 MP:0002707 abnormal kidney weight "anomaly in the heft of the organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam,Tg(Ins2-Nos2)40Okam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0004149 increased bone strength "increased ability of bone to endure the application of force without yielding or breaking" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp8tm1.1Yuan/Casp8tm1.1Yuan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * MF1

Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam,Tg(Ins2-Nos2)40Okam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Agertm1.1Hyam/Ager+,Tg(Ins2-Nos2)40Okam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2

Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam,Tg(Ins2-Nos2)40Okam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam,Tg(Ins2-Nos2)40Okam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0008124 decreased plasmacytoid dendritic cell number "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
Show

Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0011338 abnormal mesangial matrix morphology "any structural anomaly of the extracellular matrix secreted by intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0011349 abnormal renal glomerulus basement membrane thickness "increased or decreased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0020416 decreased fibroblast chemotaxis "reduction in the directed movement response of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [mgi:anna, PMID:20231695]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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