ENSG00000204305


Homo sapiens

Features
Gene ID: ENSG00000204305
  
Biological name :AGER
  
Synonyms : advanced glycosylation end-product specific receptor / AGER / Q15109
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.32
Gene start: 32180968
Gene end: 32184324
  
Corresponding Affymetrix probe sets: 210081_at (Human Genome U133 Plus 2.0 Array)   217046_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364217
Ensembl peptide - ENSP00000364211
Ensembl peptide - ENSP00000387887
Ensembl peptide - ENSP00000484081
Ensembl peptide - ENSP00000445389
Ensembl peptide - ENSP00000398466
Ensembl peptide - ENSP00000364195
Ensembl peptide - ENSP00000364196
Ensembl peptide - ENSP00000364206
Ensembl peptide - ENSP00000364208
Ensembl peptide - ENSP00000364210
NCBI entrez gene - 177     See in Manteia.
OMIM - 600214
RefSeq - XM_017010328
RefSeq - NM_001136
RefSeq - NM_001206929
RefSeq - NM_001206932
RefSeq - NM_001206934
RefSeq - NM_001206936
RefSeq - NM_001206940
RefSeq - NM_001206954
RefSeq - NM_001206966
RefSeq - NM_172197
RefSeq Peptide - NP_001193858
RefSeq Peptide - NP_001193861
RefSeq Peptide - NP_001193869
RefSeq Peptide - NP_001193883
RefSeq Peptide - NP_001193895
RefSeq Peptide - NP_751947
RefSeq Peptide - NP_001193863
RefSeq Peptide - NP_001193865
RefSeq Peptide - NP_001127
swissprot - Q3L1R2
swissprot - Q5SSZ3
swissprot - A0A1U9X785
swissprot - C0IP14
swissprot - B5A982
swissprot - A8MS87
swissprot - Q15109
swissprot - Q5SSZ2
Ensembl - ENSG00000204305
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AgerENSMUSG00000015452Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001914 regulation of T cell mediated cytotoxicity IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IGI
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007611 learning or memory IGI
 biological_processGO:0009611 response to wounding TAS
 biological_processGO:0010255 glucose mediated signaling pathway IDA
 biological_processGO:0014002 astrocyte development IEA
 biological_processGO:0031175 neuron projection development IGI
 biological_processGO:0032693 negative regulation of interleukin-10 production IDA
 biological_processGO:0032735 positive regulation of interleukin-12 production IMP
 biological_processGO:0042104 positive regulation of activated T cell proliferation IMP
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0046330 positive regulation of JNK cascade IGI
 biological_processGO:0048167 regulation of synaptic plasticity TAS
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050930 induction of positive chemotaxis IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IGI
 biological_processGO:0051101 regulation of DNA binding IEA
 biological_processGO:0061890 positive regulation of astrocyte activation IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IGI
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA
 biological_processGO:0072657 protein localization to membrane IEA
 biological_processGO:0090647 modulation of age-related behavioral decline IGI
 biological_processGO:0150003 regulation of spontaneous synaptic transmission IGI
 biological_processGO:1900271 regulation of long-term synaptic potentiation IEA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IEA
 biological_processGO:1900453 negative regulation of long term synaptic depression IGI
 biological_processGO:1900744 regulation of p38MAPK cascade IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IGI
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling NAS
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IGI
 biological_processGO:1903980 positive regulation of microglial cell activation IGI
 biological_processGO:1904597 negative regulation of connective tissue replacement involved in inflammatory response wound healing IEA
 biological_processGO:1904604 negative regulation of advanced glycation end-product receptor activity IEA
 biological_processGO:1904645 response to amyloid-beta IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:2000514 regulation of CD4-positive, alpha-beta T cell activation IDA
 biological_processGO:2001200 positive regulation of dendritic cell differentiation IMP
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0009986 cell surface NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0098794 postsynapse TAS
 molecular_functionGO:0001540 amyloid-beta binding TAS
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005044 scavenger receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0038023 signaling receptor activity IMP
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044548 S100 protein binding IEA
 molecular_functionGO:0050785 advanced glycation end-product receptor activity NAS
 molecular_functionGO:1904599 advanced glycation end-product binding IEA


Pathways (from Reactome)
Pathway description
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction / complex






 

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