ENSMUSG00000015748


Mus musculus

Features
Gene ID: ENSMUSG00000015748
  
Biological name :Prpf3
  
Synonyms : Prpf3 / Q922U1 / U4/U6 small nuclear ribonucleoprotein Prp3
  
Possible biological names infered from orthology : O43395 / pre-mRNA processing factor 3
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 95830124
Gene end: 95855885
  
Corresponding Affymetrix probe sets: 10500253 (MoGene1.0st)   1424314_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124950
Ensembl peptide - ENSMUSP00000015892
Ensembl peptide - ENSMUSP00000124302
Ensembl peptide - ENSMUSP00000124444
NCBI entrez gene - 70767     See in Manteia.
MGI - MGI:1918017
RefSeq - XM_006502080
RefSeq - XM_006502081
RefSeq - NM_001316751
RefSeq - NM_027541
RefSeq Peptide - NP_001303680
RefSeq Peptide - NP_081817
swissprot - Q922U1
swissprot - F6T4V0
swissprot - E0CYD0
Ensembl - ENSMUSG00000015748
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prpf3ENSDARG00000086425Danio rerio
 PRPF3ENSGALG00000028205Gallus gallus
 PRPF3ENSG00000117360Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002483  PWI domain
 IPR010541  Domain of unknown function DUF1115
 IPR013881  Pre-mRNA-splicing factor 3
 IPR027104  U4/U6 small nuclear ribonucleoprotein Prp3
 IPR036483  PWI domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000244 spliceosomal tri-snRNP complex assembly ISS
 biological_processGO:0000398 mRNA splicing, via spliceosome IBA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0015030 Cajal body ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0046540 U4/U6 x U5 tri-snRNP complex IBA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Abi1tm1.2Lko/Abi1tm1.2Lko
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Prpf3tm1.1Eap/Prpf3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abi1tm1.2Lko/Abi1tm1.2Lko
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Prpf3tm1.1Eap/Prpf3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abi1tm1.2Lko/Abi1tm1.2Lko
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Prpf3tm1.1Eap/Prpf3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060288 Ppih / Q9D868 / Peptidyl-prolyl cis-trans isomerase H   / complex
 ENSMUSG00000066148 Prpf4 / Q9DAW6 / pre-mRNA processing factor 4 / O43172*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr