ENSMUSG00000017119


Mus musculus

Features
Gene ID: ENSMUSG00000017119
  
Biological name :Nbr1
  
Synonyms : Nbr1 / neighbor of Brca1 gene 1 / P97432
  
Possible biological names infered from orthology : NBR1, autophagy cargo receptor / Q14596
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 101552149
Gene end: 101581951
  
Corresponding Affymetrix probe sets: 10381419 (MoGene1.0st)   1448343_a_at (Mouse Genome 430 2.0 Array)   1451897_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119900
Ensembl peptide - ENSMUSP00000102836
Ensembl peptide - ENSMUSP00000121628
Ensembl peptide - ENSMUSP00000134500
Ensembl peptide - ENSMUSP00000133619
Ensembl peptide - ENSMUSP00000122097
Ensembl peptide - ENSMUSP00000071467
Ensembl peptide - ENSMUSP00000099387
Ensembl peptide - ENSMUSP00000099388
Ensembl peptide - ENSMUSP00000102826
Ensembl peptide - ENSMUSP00000102830
Ensembl peptide - ENSMUSP00000102831
NCBI entrez gene - 17966     See in Manteia.
MGI - MGI:108498
RefSeq - XM_006532435
RefSeq - NM_001252220
RefSeq - NM_001252222
RefSeq - NM_001252223
RefSeq - NM_008676
RefSeq - XM_006532430
RefSeq - XM_006532431
RefSeq - XM_006532432
RefSeq - XM_006532433
RefSeq - XM_006532434
RefSeq Peptide - NP_001239152
RefSeq Peptide - NP_001239149
RefSeq Peptide - NP_032702
RefSeq Peptide - NP_001239151
swissprot - A2A4N7
swissprot - F6S397
swissprot - G3UZH6
swissprot - K3W4P1
swissprot - A2A4N5
swissprot - Q05BC8
swissprot - P97432
swissprot - A1L329
swissprot - A2A4R0
swissprot - A2A4N8
Ensembl - ENSMUSG00000017119
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nbr1aENSDARG00000077297Danio rerio
 nbr1bENSDARG00000078772Danio rerio
 NBR1ENSGALG00000002765Gallus gallus
 NBR1ENSG00000188554Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000433  Zinc finger, ZZ-type
 IPR009060  UBA-like superfamily
 IPR015940  Ubiquitin-associated domain
 IPR032350  Next to BRCA1, central domain
 IPR033513  Next to BRCA1 gene 1 protein
 IPR034852  NBR1, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016236 macroautophagy IBA
 biological_processGO:0030500 regulation of bone mineralization IMP
 biological_processGO:0032872 regulation of stress-activated MAPK cascade IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0051259 protein complex oligomerization ISS
 cellular_componentGO:0000407 phagophore assembly site IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031430 M band IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043130 ubiquitin binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008158 increased diameter of femur "increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0008160 increased diameter of humerus "increased width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0010929 increased osteoid thickness "increase in the width of the layer of newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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