ENSMUSG00000017754


Mus musculus

Features
Gene ID: ENSMUSG00000017754
  
Biological name :Pltp
  
Synonyms : P55065 / phospholipid transfer protein / Pltp
  
Possible biological names infered from orthology : P55058
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 164839518
Gene end: 164857711
  
Corresponding Affymetrix probe sets: 10489569 (MoGene1.0st)   1417963_at (Mouse Genome 430 2.0 Array)   1456424_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104939
Ensembl peptide - ENSMUSP00000122760
Ensembl peptide - ENSMUSP00000119955
Ensembl peptide - ENSMUSP00000104940
Ensembl peptide - ENSMUSP00000061519
NCBI entrez gene - 18830     See in Manteia.
MGI - MGI:103151
RefSeq - NM_011125
RefSeq Peptide - NP_035255
swissprot - P55065
swissprot - A2A5K4
swissprot - Q3UFS5
swissprot - A2A5K3
swissprot - A2A5K2
Ensembl - ENSMUSG00000017754
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pltpENSDARG00000104495Danio rerio
 PLTPENSGALG00000036686Gallus gallus
 PLTPENSG00000100979Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lbp / Q61805 / Lipopolysaccharide-binding protein / P18428*ENSMUSG0000001602425
Bpi / Q67E05 / Mus musculus bactericidal permeablility increasing protein (Bpi), transcript variant 2, mRNA. / P17213* / bactericidal/permeability-increasing protein*ENSMUSG0000005292224
Bpifc / BPI fold containing family C / Q8NFQ6*ENSMUSG0000005010822


Protein motifs (from Interpro)
Interpro ID Name
 IPR001124  Lipid-binding serum glycoprotein, C-terminal
 IPR017942  Lipid-binding serum glycoprotein, N-terminal
 IPR017943  Bactericidal permeability-increasing protein, alpha/beta domain superfamily
 IPR017954  Lipid-binding serum glycoprotein, conserved site
 IPR030179  Phospholipid transfer protein
 IPR030675  Lipid binding protein BPI/LBP
 IPR032942  BPI/LBP/Plunc family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006869 lipid transport ISO
 biological_processGO:0010189 vitamin E biosynthetic process IMP
 biological_processGO:0010875 positive regulation of cholesterol efflux ISO
 biological_processGO:0015914 phospholipid transport ISO
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0034375 high-density lipoprotein particle remodeling ISO
 biological_processGO:0035627 ceramide transport ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0034364 high-density lipoprotein particle ISO
 molecular_functionGO:0005319 lipid transporter activity ISO
 molecular_functionGO:0005548 phospholipid transporter activity ISO
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008429 phosphatidylethanolamine binding ISO
 molecular_functionGO:0008525 phosphatidylcholine transporter activity ISO
 molecular_functionGO:0019992 diacylglycerol binding ISO
 molecular_functionGO:0031210 phosphatidylcholine binding ISO
 molecular_functionGO:0035620 ceramide transporter activity ISO
 molecular_functionGO:0070300 phosphatidic acid binding ISO
 molecular_functionGO:0097001 ceramide binding ISO
 molecular_functionGO:1901611 phosphatidylglycerol binding ISO
 molecular_functionGO:1904121 phosphatidylethanolamine transporter activity ISO
 molecular_functionGO:1990050 phosphatidic acid transporter activity ISO


Pathways (from Reactome)
Pathway description
HDL remodeling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Pltptm2.1Jia/Pltptm2.1Jia
Genetic Background: involves: C57BL/6J

 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pltptm2.1Jia/Pltptm2.1Jia
Genetic Background: involves: C57BL/6J

 MP:0002660 abnormal caput "anomalous structure of the head of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002662 abnormal cauda "anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0003191 abnormal cellular cholesterol metabolism "impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pltptm2.1Jia/Pltptm2.1Jia
Genetic Background: involves: C57BL/6J

 MP:0003981 decreased circulating phospholipid level "reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pltptm2.1Jia/Pltptm2.1Jia
Genetic Background: involves: C57BL/6J

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pltptm2.1Jia/Pltptm2.1Jia
Genetic Background: involves: C57BL/6J

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0011231 abnormal vitamin E level "any anomaly in the concentration of vitamin E, tocopherol, including a series of eight structurally similar compounds; alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant" [GO:0010189]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0020126 decreased circulating HDL phospholipid level "decrease in the concentration in the blood of HDL phospholipid" [GOC:NV]
Show

Allelic Composition: Pltptm2.1Jia/Pltptm2.1Jia
Genetic Background: involves: C57BL/6J

 MP:0020129 decreased circulating non-HDL phospholipid level "decrease in the concentration in the blood of non-HDL phospholipid" [GOC:NV]
Show

Allelic Composition: Pltptm2.1Jia/Pltptm2.1Jia
Genetic Background: involves: C57BL/6J

 MP:0020151 abnormal circulating non-HDL cholesterol level "any anomaly in the amount in the blood of non-HDL cholesterol" [GOC:NV]
Show

Allelic Composition: Pltptm2.1Jia/Pltptm2.1Jia
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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