ENSMUSG00000018169


Mus musculus

Features
Gene ID: ENSMUSG00000018169
  
Biological name :Mfng
  
Synonyms : Beta-1,3-N-acetylglucosaminyltransferase manic fringe / Mfng / O09008
  
Possible biological names infered from orthology : MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase / O00587
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 78755882
Gene end: 78773475
  
Corresponding Affymetrix probe sets: 10430389 (MoGene1.0st)   1416992_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018313
NCBI entrez gene - 17305     See in Manteia.
MGI - MGI:1095404
RefSeq - XM_017316492
RefSeq - NM_008595
RefSeq - XM_006520551
RefSeq - XM_006520552
RefSeq Peptide - NP_032621
swissprot - O09008
swissprot - Q3UPI0
Ensembl - ENSMUSG00000018169
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mfngENSDARG00000042925Danio rerio
 MFNGENSGALG00000012442Gallus gallus
 MFNGENSG00000100060Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lfng / O09010 / Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe / Q8NES3* / LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase*ENSMUSG0000002957056
Rfng / O09009 / Beta-1,3-N-acetylglucosaminyltransferase radical fringe / Q9Y644* / RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase*ENSMUSG0000002515851


Protein motifs (from Interpro)
Interpro ID Name
 IPR003378  Fringe-like
 IPR017374  Fringe
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002315 marginal zone B cell differentiation IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0036066 protein O-linked fucosylation IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Cjg/Mfngtm1Cjg
Genetic Background: B6.Cg-Lfngtm1Rjo Mfngtm1Cjg

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0008180 abnormal marginal zone B cell morphology "any structural anomaly of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0012355 decreased prothrombin time "decreased amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation" [MPD:Molly]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0012358 decreased partial thromboplastin time "decreased amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways" [MPD:Molly]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0012616 increased circulating factor IX level 
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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