ENSMUSG00000025158


Mus musculus

Features
Gene ID: ENSMUSG00000025158
  
Biological name :Rfng
  
Synonyms : Beta-1,3-N-acetylglucosaminyltransferase radical fringe / O09009 / Rfng
  
Possible biological names infered from orthology : Q9Y644 / RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120780746
Gene end: 120784207
  
Corresponding Affymetrix probe sets: 10393944 (MoGene1.0st)   1421160_a_at (Mouse Genome 430 2.0 Array)   1460704_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026156
NCBI entrez gene - 19719     See in Manteia.
MGI - MGI:894275
RefSeq - NM_009053
RefSeq - XM_006532606
RefSeq Peptide - NP_033079
swissprot - O09009
Ensembl - ENSMUSG00000025158
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfngENSDARG00000019746Danio rerio
 RFNGENSGALG00000002841Gallus gallus
 RFNGENSG00000169733Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lfng / O09010 / Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe / Q8NES3* / LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase*ENSMUSG0000002957055
Mfng / O09008 / Beta-1,3-N-acetylglucosaminyltransferase manic fringe / O00587* / MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase*ENSMUSG0000001816949


Protein motifs (from Interpro)
Interpro ID Name
 IPR003378  Fringe-like
 IPR017374  Fringe


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0036066 protein O-linked fucosylation IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
Show

Allelic Composition: En1tm1Alj/En1tm1Alj,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: En1tm1Alj/En1tm1Alj,Rfngtm1Tfv/Rfng+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: FVB/N

Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: En1tm1Alj/En1tm1Alj,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008149 abnormal rib-vertebral column attachment "any anomaly in the in the normal joining of the ribs to the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

Allelic Composition: Rfngtm2Tfv/Rfngtm2Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr