ENSMUSG00000018217


Mus musculus

Features
Gene ID: ENSMUSG00000018217
  
Biological name :Pmp22
  
Synonyms : peripheral myelin protein 22 isoform 2 / Pmp22
  
Possible biological names infered from orthology : peripheral myelin protein 22 / Q01453
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 63128982
Gene end: 63159547
  
Corresponding Affymetrix probe sets: 10376950 (MoGene1.0st)   1417133_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104340
Ensembl peptide - ENSMUSP00000104341
Ensembl peptide - ENSMUSP00000104342
Ensembl peptide - ENSMUSP00000018361
NCBI entrez gene - 18858     See in Manteia.
MGI - MGI:97631
RefSeq - NM_008885
RefSeq - NM_001302260
RefSeq - NM_001302255
RefSeq - NM_001302257
RefSeq - NM_001302258
RefSeq - NM_001302259
RefSeq - NM_001302261
RefSeq Peptide - NP_001289184
RefSeq Peptide - NP_001289186
RefSeq Peptide - NP_001289187
RefSeq Peptide - NP_001289188
RefSeq Peptide - NP_001289189
RefSeq Peptide - NP_001289190
RefSeq Peptide - NP_032911
swissprot - Q5SXS3
Ensembl - ENSMUSG00000018217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pmp22aENSDARG00000105223Danio rerio
 pmp22bENSDARG00000060457Danio rerio
 PMP22ENSGALG00000031425Gallus gallus
 PMP22ENSG00000109099Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Emp3 / O35912 / Epithelial membrane protein 3 / P54852*ENSMUSG0000004021244
Emp2 / O88662 / Epithelial membrane protein 2 / P54851*ENSMUSG0000002250543
Emp1 / P47801 / Epithelial membrane protein 1 / P54849*ENSMUSG0000003020838


Protein motifs (from Interpro)
Interpro ID Name
 IPR003936  Peripheral myelin protein PMP22
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR004032  PMP-22/EMP/MP20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0042552 myelination IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043218 compact myelin IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr-J/?
Genetic Background: involves: C57BL/6J

Allelic Composition: Pmp22Tr/?
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr/Pmp22Tr
Genetic Background: Not Specified

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv

Allelic Composition: Pmp22Tr-3H/Pmp22+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Pmp22Tr-2H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-1H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Mhdatre002/Pmp22Mhdatre002
Genetic Background: C3HeB/FeJ-Pmp22Mhdatre002

Allelic Composition: Pmp22M1247Lja/Pmp22+
Genetic Background: involves: C57BL/6J * DBA

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr/Pmp22Tr
Genetic Background: Not Specified

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv

 MP:0000756 forelimb paralysis "loss of power of voluntary movement in muscles of the forlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr-J/?
Genetic Background: involves: C57BL/6J

Allelic Composition: Pmp22Tr/?
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: involves: C57BL/6

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv

Allelic Composition: Pmp22tm1Ueli/Pmp22+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pmp22Tr-Ncnp/Pmp22Tr-Ncnp
Genetic Background: GAD/Ncnp-Pmp22Tr-Ncnp

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr/Pmp22Tr
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

Allelic Composition: Pmp22Tr-3H/Pmp22+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Pmp22Tr-2H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-1H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-Ncnp/Pmp22+
Genetic Background: GAD/Ncnp-Pmp22Tr-Ncnp

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: involves: C57BL/6

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr-J/?
Genetic Background: involves: C57BL/6J

Allelic Composition: Pmp22Tr/?
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr/Pmp22Tr
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: involves: C57BL/6

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pmp22Tr/?
Genetic Background: involves: CBA

Allelic Composition: Pmp22Tr-3H/Pmp22+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Pmp22Tr-2H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-1H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-Ncnp/Pmp22Tr-Ncnp
Genetic Background: GAD/Ncnp-Pmp22Tr-Ncnp

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Pmp22Tr-3H/Pmp22+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Pmp22Tr-2H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-1H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pmp22Tr/Pmp22Tr
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr-3H/Pmp22+
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr-J/?
Genetic Background: involves: C57BL/6J

Allelic Composition: Pmp22Tr/?
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr/Pmp22Tr
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: involves: C57BL/6

Allelic Composition: Pmp22Tr-3H/Pmp22+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Pmp22Tr-2H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-1H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-Ncnp/Pmp22+
Genetic Background: GAD/Ncnp-Pmp22Tr-Ncnp

Allelic Composition: Pmp22Tr-Ncnp/Pmp22Tr-Ncnp
Genetic Background: GAD/Ncnp-Pmp22Tr-Ncnp

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr/?
Genetic Background: Not Specified

Allelic Composition: Pmp22tm1Ueli/Pmp22+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Pmp22Tr-3H/Pmp22+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Pmp22Tr-2H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-1H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Pmp22Tr-3H/Pmp22+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Pmp22Tr-2H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-1H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr-J/?
Genetic Background: involves: C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr/?
Genetic Background: Not Specified

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pmp22Mhdatre002/Pmp22Mhdatre002
Genetic Background: C3HeB/FeJ-Pmp22Mhdatre002

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv

Allelic Composition: Pmp22tm1Ueli/Pmp22+
Genetic Background: involves: 129S/SvEv

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: involves: C57BL/6

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv

Allelic Composition: Pmp22tm1Ueli/Pmp22+
Genetic Background: involves: 129S/SvEv

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pmp22Tr-J/?
Genetic Background: involves: C57BL/6J

Allelic Composition: Pmp22Tr-3H/Pmp22+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Pmp22Tr-2H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-1H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pmp22Tr/?
Genetic Background: Not Specified

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Pmp22Tr-3H/Pmp22+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Pmp22Tr-2H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

Allelic Composition: Pmp22Tr-1H/Pmp22+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

 MP:0010742 increased Schwann cell number "greater than normal number of cells that sheath the axons of the peripheral nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pmp22Tr-J/?
Genetic Background: involves: C57BL/6J

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Pmp22Tr/Pmp22+
Genetic Background: Not Specified

 MP:0011731 decreased myelin sheath thickness "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
Show

Allelic Composition: Pmp22Tr-J/?
Genetic Background: involves: C57BL/6J

 MP:0011904 abnormal Schwann cell physiology "any functional anomaly of the cells which form the insulating myelin sheaths of peripheral axons" [MESH:A08.637.800]
Show

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011906 increased Schwann cell proliferation "increase in the expansion rate of a Schwann cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Pmp22tm1Ueli/Pmp22tm1Ueli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0012051 spasticity "a motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes and increased resistance to stretch" [HP:0001257, MGI:csmith]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
Show

Allelic Composition: Pmp22Tr-J/?
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr