Manteia

ENSMUSG00000018548

Mus musculus

Features

Gene ID:	ENSMUSG00000018548

Biological name :	Trim37

Synonyms :	E3 ubiquitin-protein ligase TRIM37 / Q6PCX9 / Trim37

Possible biological names infered from orthology :	O94972 / tripartite motif containing 37

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	C
Gene start:	87127077
Gene end:	87220683

Corresponding Affymetrix probe sets:	10379998 (MoGene1.0st) 1434554_at (Mouse Genome 430 2.0 Array) 1435604_at (Mouse Genome 430 2.0 Array) 1436393_a_at (Mouse Genome 430 2.0 Array) 1436394_at (Mouse Genome 430 2.0 Array) 1455012_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000049057 Ensembl peptide - ENSMUSP00000118260 Ensembl peptide - ENSMUSP00000119269 NCBI entrez gene - 68729 See in Manteia. MGI - MGI:2153072 RefSeq - XM_011249212 RefSeq - NM_197987 RefSeq - XM_006534072 RefSeq - XM_011249209 RefSeq - XM_011249210 RefSeq - XM_011249211 RefSeq Peptide - NP_932104 swissprot - Q5SQY9 swissprot - Q6PCX9 swissprot - F6XMH5 Ensembl - ENSMUSG00000018548

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
trim37	ENSDARG00000076473	Danio rerio
TRIM37	ENSGALG00000005084	Gallus gallus
O94972	ENSG00000108395	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000315	B-box-type zinc finger
IPR001841	Zinc finger, RING-type
IPR002083	MATH/TRAF domain
IPR003649	B-box, C-terminal
IPR008974	TRAF-like
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR037299	TRIM37, MATH domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0016567	protein ubiquitination	IEA
biological_process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IEA
biological_process	GO:0035518	histone H2A monoubiquitination	IMP
biological_process	GO:0036353	histone H2A-K119 monoubiquitination	IEA
biological_process	GO:0046600	negative regulation of centriole replication	IEA
biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IEA
biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IEA
biological_process	GO:0051865	protein autoubiquitination	IEA
biological_process	GO:0070842	aggresome assembly	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005777	peroxisome	ISO
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0016235	aggresome	IEA
cellular_component	GO:0035098	ESC/E(Z) complex	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	IEA
molecular_function	GO:0005164	tumor necrosis factor receptor binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0031625	ubiquitin protein ligase binding	IEA
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0061630	ubiquitin protein ligase activity	IEA

Pathways (from Reactome)

Pathway description

Antigen processing: Ubiquitination & Proteasome degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0000602	enlarged sinusoidal spaces	"larger than normal sized cavities in the liver " [J:23170]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001116	small gonad	"reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001152	Leydig cell hyperplasia	"increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001750	increased circulating follicle stimulating hormone level	"higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001751	increased circulating luteinizing hormone level	"higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0001944	abnormal pancreas morphology	"malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0002016	ovarian cysts	"cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0002038	carcinoma	"malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0002786	abnormal Leydig cell morphology	"malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0003450	enlarged pancreas	"increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0004067	abnormal ventricular trabeculae morphology	"aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0004805	absent oocytes	"absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0004806	absent germ cells	"absence of germ cells, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0005324	ascites	"accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0005330	cardiomyopathy	"diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0005352	small skull	"less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0005431	oocyte depletion	"reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0006283	medulloblastoma	"a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0006362	abnormal male germ cell morphology	"any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0008000	ovary tumor	"presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0008526	decreased skull width	"having a decreased side-to-side distance of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0011942	decreased fluid intake	"reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0013279	increased fasted circulating glucose level	"increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont
MP:0013600	testis degeneration	"a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]	Show Allelic Composition: Chrnb2^tm1.1Cont/Chrnb2⁺ Genetic Background: B6.129-Chrnb2^tm1.1Cont

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr