ENSMUSG00000018861


Mus musculus

Features
Gene ID: ENSMUSG00000018861
  
Biological name :Fdxr
  
Synonyms : Fdxr / ferredoxin reductase / Q61578
  
Possible biological names infered from orthology : P22570
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 115268024
Gene end: 115277050
  
Corresponding Affymetrix probe sets: 10392881 (MoGene1.0st)   1416806_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021078
NCBI entrez gene - 14149     See in Manteia.
MGI - MGI:104724
RefSeq - NM_007997
RefSeq - XM_006532186
RefSeq Peptide - NP_032023
swissprot - Q61578
Ensembl - ENSMUSG00000018861
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fdxrENSDARG00000089369Danio rerio
 FDXRENSGALG00000035816Gallus gallus
 FDXRENSG00000161513Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021163  Ferredoxin-NADP+ reductase, adrenodoxin-type
 IPR023753  FAD/NAD(P)-binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006744 ubiquinone biosynthetic process IBA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070995 NADPH oxidation IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0015039 NADPH-adrenodoxin reductase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0070402 NADPH binding IEA


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis
Endogenous sterols
Electron transport from NADPH to Ferredoxin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0006149 blurred vision "loss of visiual acuity or ability to distinguish small details" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018861 Fdxr / Q61578 / ferredoxin reductase / P22570*  / reaction
 ENSMUSG00000032051 Fdx1 / P46656 / ferredoxin 1 / P10109*  / complex / reaction
 ENSMUSG00000032323 Q9QZ82 / Cyp11a1 / Cholesterol side-chain cleavage enzyme, mitochondrial / P05108* / cytochrome P450 family 11 subfamily A member 1*  / complex / reaction






 

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