ENSG00000161513


Homo sapiens

Features
Gene ID: ENSG00000161513
  
Biological name :FDXR
  
Synonyms : FDXR / ferredoxin reductase / P22570
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.1
Gene start: 74862497
Gene end: 74873031
  
Corresponding Affymetrix probe sets: 207813_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462488
Ensembl peptide - ENSP00000462330
Ensembl peptide - ENSP00000462884
Ensembl peptide - ENSP00000464670
Ensembl peptide - ENSP00000463940
Ensembl peptide - ENSP00000463934
Ensembl peptide - ENSP00000463308
Ensembl peptide - ENSP00000462972
Ensembl peptide - ENSP00000293195
Ensembl peptide - ENSP00000408595
Ensembl peptide - ENSP00000414172
Ensembl peptide - ENSP00000416515
Ensembl peptide - ENSP00000445432
Ensembl peptide - ENSP00000461993
Ensembl peptide - ENSP00000462083
Ensembl peptide - ENSP00000462183
NCBI entrez gene - 2232     See in Manteia.
OMIM - 103270
RefSeq - XM_011524533
RefSeq - NM_001258012
RefSeq - NM_001258013
RefSeq - NM_001258014
RefSeq - NM_001258015
RefSeq - NM_001258016
RefSeq - NM_004110
RefSeq - NM_024417
RefSeq - XM_006721772
RefSeq - XM_011524527
RefSeq - XM_011524528
RefSeq - XM_011524529
RefSeq - XM_011524531
RefSeq - XM_011524532
RefSeq Peptide - NP_001244944
RefSeq Peptide - NP_001244945
RefSeq Peptide - NP_004101
RefSeq Peptide - NP_077728
RefSeq Peptide - NP_001244941
RefSeq Peptide - NP_001244942
RefSeq Peptide - NP_001244943
swissprot - J3QSF9
swissprot - A0A0C4DGN7
swissprot - A0A0C4DFN8
swissprot - A0A0A0MTR6
swissprot - A0A0A0MTN9
swissprot - A0A0A0MT64
swissprot - J3KRG8
swissprot - J3KS64
swissprot - J3KTA3
swissprot - J3QKZ8
swissprot - J3QQW7
swissprot - P22570
swissprot - A0A0A0MSZ4
swissprot - J3QQX3
Ensembl - ENSG00000161513
  
Related genetic diseases (OMIM): 617717 - Auditory neuropathy and optic atrophy, 617717
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fdxrENSDARG00000089369Danio rerio
 FDXRENSGALG00000035816Gallus gallus
 FdxrENSMUSG00000018861Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021163  Ferredoxin-NADP+ reductase, adrenodoxin-type
 IPR023753  FAD/NAD(P)-binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006091 generation of precursor metabolites and energy TAS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process TAS
 biological_processGO:0006700 C21-steroid hormone biosynthetic process TAS
 biological_processGO:0006744 ubiquinone biosynthetic process IBA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0016125 sterol metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070995 NADPH oxidation IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004324 ferredoxin-NADP+ reductase activity TAS
 molecular_functionGO:0015039 NADPH-adrenodoxin reductase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0070402 NADPH binding IEA


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis
Endogenous sterols
Electron transport from NADPH to Ferredoxin
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137714 FDX1 / P10109 / ferredoxin 1  / complex / reaction
 ENSG00000140459 P05108 / CYP11A1 / cytochrome P450 family 11 subfamily A member 1  / reaction / complex
 ENSG00000267673 FDX2 / Q6P4F2 / ferredoxin 2  / complex / reaction
 ENSG00000161513 FDXR / P22570 / ferredoxin reductase  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr