ENSG00000137714


Homo sapiens

Features
Gene ID: ENSG00000137714
  
Biological name :FDX1
  
Synonyms : FDX1 / ferredoxin 1 / P10109
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q22.3
Gene start: 110429883
Gene end: 110464881
  
Corresponding Affymetrix probe sets: 203646_at (Human Genome U133 Plus 2.0 Array)   203647_s_at (Human Genome U133 Plus 2.0 Array)   239161_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000260270
NCBI entrez gene - 2230     See in Manteia.
OMIM - 103260
RefSeq - NM_004109
RefSeq Peptide - NP_004100
swissprot - P10109
Ensembl - ENSG00000137714
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fdx1ENSDARG00000056410Danio rerio
 FDX1ENSGALG00000026507Gallus gallus
 Fdx1ENSMUSG00000032051Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FDX2 / Q6P4F2 / ferredoxin 2ENSG0000026767327
AC011511.1ENSG0000016780717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001041  2Fe-2S ferredoxin-type iron-sulfur binding domain
 IPR001055  Adrenodoxin
 IPR012675  Beta-grasp domain superfamily
 IPR018298  Adrenodoxin, iron-sulphur binding site
 IPR036010  2Fe-2S ferredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006700 C21-steroid hormone biosynthetic process TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0016125 sterol metabolic process TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0042446 hormone biosynthetic process IDA
 biological_processGO:0044281 small molecule metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:1904322 cellular response to forskolin IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005759 mitochondrial matrix TAS
 molecular_functionGO:0005506 iron ion binding TAS
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding IDA


Pathways (from Reactome)
Pathway description
Mitochondrial iron-sulfur cluster biogenesis
Pregnenolone biosynthesis
Endogenous sterols
Electron transport from NADPH to Ferredoxin
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000161513 FDXR / P22570 / ferredoxin reductase  / reaction / complex
 ENSG00000137714 FDX1 / P10109 / ferredoxin 1  / reaction
 ENSG00000267673 FDX2 / Q6P4F2 / ferredoxin 2  / reaction
 ENSG00000140459 P05108 / CYP11A1 / cytochrome P450 family 11 subfamily A member 1  / complex / reaction






 

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